DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and MASP2

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	281	Identity:	76/281 - (27%)
Similarity:	116/281 - (41%)	Gaps:	52/281 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PITDPQCGFVNSKGVTFSFREEDTGLAQEAEVPWMVALLDARTSSYVAGGALIAPHVVITARQRT 151
            |:.:|.||.   ...|...|......|:..:.||.|.:|...|    |.|||:..:.|:||....
Human   428 PVCEPVCGL---SARTTGGRIYGGQKAKPGDFPWQVLILGGTT----AAGALLYDNWVLTAAHAV 485

  Fly   152 --ENMTASQLVVRAG-----------EWDFSTKTEQLPSVDVPIRSIVRHPGFNLENG-ANNVAL 202
              :...||.|.:|.|           .|.               .::..|.|:..:.| .|::||
Human   486 YEQKHDASALDIRMGTLKRLSPHYTQAWS---------------EAVFIHEGYTHDAGFDNDIAL 535

  Fly   203 VFLRRSLTSSRHINPICMP-----SAPKNFDFSRCIFTGWG--KNSFDDPSYMNVLKKISLPVVQ 260
            :.|...:..:.:|.|||:|     |..:..|....  :|||  :..|    ....|..:.:|:|.
Human   536 IKLNNKVVINSNITPICLPRKEAESFMRTDDIGTA--SGWGLTQRGF----LARNLMYVDIPIVD 594

  Fly   261 RRTCEQQLRLYYGNDFELDNSLMCAGGEP-GKDSCEGDGGSPLACAIKDNPQRYELAGIVNFG-V 323
            .:.|.............:..:::|||.|. |||||.||.|..|. .:....:|:.:.|||::| :
Human   595 HQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALV-FLDSETERWFVGGIVSWGSM 658

  Fly   324 DCGLPGVPAVYTNVANVIEWI 344
            :||..|...|||.|.|.|.||
Human   659 NCGEAGQYGVYTKVINYIPWI 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	68/253 (27%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	68/253 (27%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512	1/1 (100%)
		Tryp_SPc	444..679	CDD:214473	69/260 (27%)
		Tryp_SPc	445..682	CDD:238113	70/261 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910