DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and tmprss6

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	100/347 - (28%)
Similarity:	162/347 - (46%)	Gaps:	65/347 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AQGQNAEL-NQ-------SCGASN----EHQCVPRHMCKVKIEFRMAMTYRNLGCVSTAICCPKN 74
            |.|.:.|| ||       :|||.|    :..||.:               .|..|.|.|.|
Frog   506 ANGTDEELCNQGANFPTAACGAFNYKCADGSCVQK---------------PNAECDSIADC---- 551

  Fly    75 LIIKEPRLIINEPITDPQCGF-VNSKGVTFSFREEDTGLAQEAEVPWMVALLDARTSSYVAGGAL 138
                      .:...:..||. :.:.|:    |......|||.|.||. |.|..| ..::.||.|
Frog   552 ----------PDGSDENNCGCGIQAVGI----RLVGGTQAQEGEWPWQ-ASLQVR-GEHICGGTL 600

  Fly   139 IAPHVVITARQ--RTENMTASQL-VVRAGEWDFSTKTEQLPSVDVPIRSIVRHPGFNLENGANNV 200
            :|...::||..  ..|:..:.:: .|..|:...|..|::..:..| ||.:: ||.::.::...:|
Frog   601 VADQWILTAAHCFTPESYASPEVWTVYLGKVRLSRSTQKELAFKV-IRLVI-HPFYDEDSHDYDV 663

  Fly   201 ALVFLRRSL-TSSRHINPICMPSAPKNFDF-SRCIFTGWGKNSFDDPSYMNVLKKISLPVVQRRT 263
            |||.|...: .:|.|:.|||:||:..:|.. |.|..||||....:.|: .:||:|:.:.:|.:..
Frog   664 ALVLLDHLVPLTSPHVQPICLPSSTHHFPTGSSCWVTGWGSVKENGPT-SDVLQKVDIQLVAQDI 727

  Fly   264 CEQQLRLYYGNDFELDNSLMCAGGEPG-KDSCEGDGGSPLACAIKDNPQRYELAGIVNFGVDCGL 327
            |.:..|      :::...::|||...| ||:|:||.||||.|  |....|:..||:|::|..||:
Frog   728 CTELYR------YQISPRMLCAGYRDGSKDACQGDSGSPLVC--KTASGRWFQAGLVSWGAGCGI 784

  Fly   328 PGVPAVYTNVANVIEWITLTTV 349
            |....||:.:..:::||...|:
Frog   785 PRYFGVYSRITRLVQWIESITL 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	76/236 (32%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	76/236 (32%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060	3/7 (43%)
		LDLa	525..560	CDD:238060	11/63 (17%)
		Tryp_SPc	572..804	CDD:238113	78/244 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910