DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimA and SCARF2

DIOPT Version :9

Sequence 1:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens

Alignment Length:	543	Identity:	127/543 - (23%)
Similarity:	183/543 - (33%)	Gaps:	152/543 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CMEIPPRCATFKTEMREVMRVQKLNKTRTVRFCCQGYEGNLSDSQATCKPICRGG--CGR--GSC 140
            |.....||.|.:...         |.|:..:.|..|:.|  ......|.| ||.|  |..  |.|
Human   295 CTVAEGRCLTCEPGW---------NGTKCDQPCATGFYG--EGCSHRCPP-CRDGHACNHVTGKC 347

  Fly   141 VMPDICSCEEGYIGKHCTQRCDHDRWGLDCKNLC-QCQNGAACDNKSGLCHCIAGWTGQFCELPC 204
            .     .|..|:||..|..:|.:..:|.||..:| .|.:| .||.:||.|.|..|..|..|.:.|
Human   348 T-----RCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSG-HCDFQSGRCLCSPGVHGPHCNVTC 406

  Fly   205 PQGTYGIMCRKACDCDEKPCNPQTGACIQQDQPLQ--LNVSHVIVETVNSTLEKMGII------- 260
            |.|.:|..|.:||.|.|..|:|.||||..:....:  :....::|..|...|..:|..
Human   407 PPGLHGADCAQACSCHEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKD 471

  Fly   261 ----PRPTTPVPLPEV------------IVIKQPTSNENAQHSPKIIV-HQSSSDLLENLHTAAA 308
                |||...:.|...            |.:|.|......|..||::| |....:.|........
Human   472 PTRRPRPRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPP 536

  Fly   309 AGVPTPEVIHVITNGITSPQEHLAGFVGGEANSSQTATADHQSGLVVTLVSIMLLLLVAIAVGSL 373
            :|:..|           ||.      ....|:.|...|.|.                     |.:
Human   537 SGLEQP-----------SPS------WSSRASFSSFDTTDE---------------------GPV 563

  Fly   374 YVYRRYHHKNAAVYNANGTVTTLPANPEVVLTEAAVLGKNFHEPLPEP-PVAFAVTPQSNEAQ-- 435
            |.   ..|:.|...:.:..|.|:||       ||         |.|.| |:   .||.|.|..
Human   564 YC---VPHEEAPAESRDPEVPTVPA-------EA---------PAPSPVPL---TTPASAEEAIP 606

  Fly   436 -PELYDSPSNNSSIKTPP---YA-YARKESLYSVVSPKSRKGSLDSHLYDEIRYHQQHHHQQHHP 495
             |...||..:.||::.|.   || .||:|:     .|...:|.:..     :........::..|
Human   607 LPASSDSERSASSVEGPGGALYARVARREA-----RPARARGEIGG-----LSLSPSPERRKPPP 661

  Fly   496 R--------SHQHVQHSTTASQFLPARPQIMPANDQFSNGSVH---PHQRSHHVTHLIIP----- 544
            .        |..|.:||..|:...|:.|.  |.::...:.|..   |..:|.|......|
Human   662 PDPATKPKVSWIHGKHSAAAAGRAPSPPP--PGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDP 724

  Fly   545 -------PQNSNFLQVPAQITAK 560
                   |:.:..|..|:...|:
Human   725 TPRPPGLPEEATALAAPSPPRAR 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimA	NP_001285918.1	EMI	52..116	CDD:284877	7/35 (20%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	12/30 (40%)
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021	57/286 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871		46/209 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900