DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimA and Pear1

DIOPT Version :9

Sequence 1:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001027585.1	Gene:	Pear1 / 73182	MGIID:	1920432	Length:	1034	Species:	Mus musculus

Alignment Length:	228	Identity:	71/228 - (31%)
Similarity:	101/228 - (44%)	Gaps:	37/228 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLAMVLPLGSGQNSTLKINTNVKDIEAGVVALPSIQGPGNICIREEPYVEHVQVPEMQPVRVR 75
            |||||:.|.|      |..:|:|                ..|:|...|.:....:...::|..:.
Mouse     6 LLLLALGLRL------TGTLNSN----------------DPNVCTFWESFTTTTKESHLRPFSLL 48

  Fly    76 TSSWC---MEIPPRCA----TFKTEMREVMRVQKLNKTRTVRFCCQGYEGNLSDSQATCKPICRG 133
            .:..|   .|.|..||    .::|..|:|:::....:.:    ||:||    .:|:..|.|:|..
Mouse    49 PAESCHRPWEDPHTCAQPTVVYRTVYRQVVKMDSRPRLQ----CCRGY----YESRGACVPLCAQ 105

  Fly   134 GCGRGSCVMPDICSCEEGYIGKHCTQRCDHDRWGLDCKNLCQCQNGAACDNKSGLCHCIAGWTGQ 198
            .|..|.||.|:.|.|..|:.|..|:..|....||..|...|.|.|.::||.|||.|.|.:|....
Mouse   106 ECVHGRCVAPNQCQCAPGWRGGDCSSECAPGMWGPQCDKFCHCGNNSSCDPKSGTCFCPSGLQPP 170

  Fly   199 FCELPCPQGTYGIMCRKACDCDEKPCNPQTGAC 231
            .|..|||.|.||..|:..|.|....|:||.|||
Mouse   171 NCLQPCPAGHYGPACQFDCQCYGASCDPQDGAC 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimA	NP_001285918.1	EMI	52..116	CDD:284877	14/70 (20%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	12/29 (41%)
Pear1	NP_001027585.1	EMI	25..93	CDD:284877	16/75 (21%)
		EGF_CA	535..580	CDD:304395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..1034
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24052
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930