DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimA and megf6b

DIOPT Version :9

Sequence 1:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	XP_009304569.1	Gene:	megf6b / 557764	ZFINID:	ZDB-GENE-101112-3	Length:	1589	Species:	Danio rerio

Alignment Length:	135	Identity:	50/135 - (37%)
Similarity:	67/135 - (49%)	Gaps:	21/135 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 CCQGYEGNLSDSQATCKPICRGG-----------C--GRGSC-VMPDICSCEEGYIGKHCTQRCD 162
            |..|:.|:      .|:.:|..|           |  ..|.| .....|.||.|:.|..|.|:|.
Zfish   876 CPPGWTGH------NCRKVCDAGRWGLDCESVCDCRNADGVCDAQTGRCHCEAGFTGARCDQKCP 934

  Fly   163 HDRWGLDCKNLCQCQNGAACDNKSGLCHCIAGWTGQFCELPCPQGTYGIMCRKACDC-DEKPCNP 226
            ...:|..||:.|||:|.|:||:..|.|.|..||||.|||.|||||.||:.|::.|.| :...|:.
Zfish   935 AGSFGPGCKHRCQCENQASCDHVGGACTCKTGWTGTFCEKPCPQGFYGLDCQQKCVCLNGGLCDH 999

  Fly   227 QTGAC 231
            .:|.|
Zfish  1000 VSGQC 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimA	NP_001285918.1	EMI	52..116	CDD:284877	1/3 (33%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	16/29 (55%)
megf6b	XP_009304569.1	EMI	33..102	CDD:284877
		FXa_inhibition	152..187	CDD:291342
		vWFA	<184..227	CDD:294047
		FXa_inhibition	234..270	CDD:291342
		FXa_inhibition	276..311	CDD:291342
		vWFA	<308..350	CDD:294047
		FXa_inhibition	363..398	CDD:291342
		vWFA	<396..436	CDD:294047
		FXa_inhibition	445..480	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900