DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NimA and Megf6

DIOPT Version :9

Sequence 1:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001156449.1	Gene:	Megf6 / 230971	MGIID:	1919351	Length:	1572	Species:	Mus musculus

Alignment Length:	157	Identity:	59/157 - (37%)
Similarity:	76/157 - (48%)	Gaps:	24/157 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 CCQGYEGNLSDSQA--------TCKPICRGGCGRGSC-VMPDICSCEEGYIGKHCTQRCDHDRWG 167
            |..|:.| ||..:|        .|...|....|.|:| .:..:|.||.||.|..|.|.|....:|
Mouse   849 CAPGWTG-LSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYEGPQCEQWCRQGYFG 912

  Fly   168 LDCKNLCQCQNGAACDNKSGLCHCIAGWTGQFCELPCPQGTYGIMCRKACDCDE-KPCNPQTGAC 231
            ..|:..|:|::||.||:.||.|.|.|||.|.|||..||.|.:|:.|..||:|.. .||:..||:|
Mouse   913 PGCEQKCRCEHGATCDHVSGACTCPAGWRGSFCEHACPAGFFGLDCGSACNCSAGAPCDAVTGSC 977

  Fly   232 I-----------QQDQPLQ--LNVSHV 245
            |           |...||.  ||.|.:
Mouse   978 ICPAGRWGPHCAQTCPPLTFGLNCSQI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimA	NP_001285918.1	EMI	52..116	CDD:284877	1/3 (33%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	15/29 (52%)
Megf6	NP_001156449.1	EMI	42..111	CDD:284877
		FXa_inhibition	126..161	CDD:291342
		vWFA	<153..201	CDD:294047
		vWFA	<236..284	CDD:294047
		vWFA	<283..324	CDD:294047
		FXa_inhibition	337..372	CDD:291342
		vWFA	<370..409	CDD:294047
		vWFA	<412..451	CDD:294047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900