DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NimA and Stab1

DIOPT Version :9

Sequence 1:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	XP_008769275.1	Gene:	Stab1 / 100363145	RGDID:	2324745	Length:	2630	Species:	Rattus norvegicus

Alignment Length:	723	Identity:	151/723 - (20%)
Similarity:	230/723 - (31%)	Gaps:	268/723 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLLAMVLPL-GSG--QNSTLKINTNVKDIEAGVVALPSIQGPGNICIREEPYVEHVQVPEMQP 71
            ||||..:||.| |||  :..|::                     ...|.....::.|........
  Rat     7 LLLLCILVLCLAGSGFIRGQTVR---------------------SKRCDIHTKFITHTPCTACAA 50

  Fly    72 VRVR--TSSWCMEIPPRC---ATFKTEMR-EVMRV----QKLNKTRTVRFCCQGYEGNLSDSQAT 126
            :|.|  .|.|....|.:.   ..::.::| .|:.:    |:..|....:.||.||.|      :.
  Rat    51 IRRRLCPSGWSRNFPEKILLDCRYELQLRGSVVSLSGCSQECWKDVVQKACCPGYWG------SQ 109

  Fly   127 CKPICRGG----C-GRGSCVMPD------ICSCEEGYIGKHCTQRCDHDRWGLDCKNLCQCQNGA 180
            |.. |.||    | |.|:|:  |      .|.|:|.:.|..|....|.:|:|.||:::|.|.:|
  Rat   110 CYE-CPGGPATPCSGHGTCL--DGIGGNGTCVCQENFSGSACQDCRDPNRFGPDCQSVCNCVHG- 170

  Fly   181 ACD---NKSGLCHCIAGWTGQFC--ELP------CPQGTYGIMCRKACDCDEKPCN------PQT 228
            .|.   ..:|.|.|.||:||..|  |||      |||.:       .|..:...|.      .|.
  Rat   171 VCSRGPQGNGSCQCFAGYTGPHCDQELPVCQSLRCPQNS-------QCSAEAPACKCLPGYIQQD 228

  Fly   229 GACIQQD-QPLQLNVSHVIVETVNSTLEKMGIIPRPTTPVPLPEVIVIKQPTSN--ENAQHSPKI 290
            .||:::. .|.|                     |.|.:.:....|....||..:  ||.....|:
  Rat   229 NACLREPLDPCQ---------------------PSPCSSLARCSVTPSGQPQCHCPENYHGDGKV 272

  Fly   291 IVHQS-----------------------------------SSDLLENLHTA--------AAAGVP 312
            .:.|.                                   ::|..|..|.:        :|....
  Rat   273 CLPQDPCLTNFGGCPSNSTFCLYRAPGKATCMCWPGMTSINNDASEGCHVSCKPHSCDKSATCQV 337

  Fly   313 TPEVIHVITNGITSPQEHLAGFV--GGEANSSQTATADHQSGLVVTLVSIMLLLLVAIAV----- 370
            ||:   ..|:.:....|...|:.  |...:..|.|   :|.|||      :|.|.||||:
  Rat   338 TPD---RKTSCVCKSDEVGDGYACYGHLLHEVQRA---NQIGLV------LLRLRVAIAMLEQGC 390

  Fly   371 -------GSLYVYRRYHHKNAAVYNANGTVTTL-------------------PANPEVVLT---- 405
                   |...|........:|:.::|...|..                   |:|.....|
  Rat   391 QEILTTSGPFTVLVPSMFSVSAISSSNMNATLAQQLCRQHIIPGEHILENIGPSNTRRWWTLAGQ 455

  Fly   406 EAAVLGKNF-----HEPLPEP------------PVAFAVTPQSNEAQPELYDSPSNN-SSIKTPP 452
            |..|..||.     :|..|:.            .|...||....:..|.|...|... ..|....
  Rat   456 EITVTFKNLRYSYKYEDQPQQFSIQKANYIAANGVFHTVTALRWQLPPPLPGDPKKTVGQILAST 520

  Fly   453 YAYARKESL---------------YSVVSPKS------RKGSLD-------SHLYDEIRYHQQHH 489
            .|:.|.|::               ::|.:|.:      |.|.|.       |.|.:.:|||..:|
  Rat   521 EAFTRFETILENCGLPAMLDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAGLSKLQELVRYHIYNH 585

  Fly   490 HQQHHPRSHQHVQHSTTASQFL-----------------PARPQIMPANDQFSNGSVHPHQRSHH 537
            .|....:.....:..|.|:|.|                 |.|...:||    :||.:      |.
  Rat   586 GQLTVEKLISKGRFLTMANQVLTVNISEEGRILLGPEGVPVRRVDVPA----ANGVI------HM 640

  Fly   538 VTHLIIPP 545
            :..:::||
  Rat   641 LEGILLPP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NimA	NP_001285918.1	EMI	52..116	CDD:284877	13/73 (18%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	12/32 (38%)
Stab1	XP_008769275.1	Fasciclin	391..494	CDD:295423	15/102 (15%)
		Fasciclin	523..647	CDD:280607	25/133 (19%)
		EGF_3	834..863	CDD:289699
		EGF_3	918..949	CDD:289699
		EGF_3	955..991	CDD:289699
		Fasciclin	<1100..1180	CDD:280607
		Fasciclin	1224..1313	CDD:295423
		EGF_3	1519..1555	CDD:289699
		EGF_3	1561..1595	CDD:289699
		EGF_3	1604..1641	CDD:289699
		Fasciclin	1666..1770	CDD:280607
		Fasciclin	1796..1926	CDD:280607
		EGF_Lam	2037..2082	CDD:238012
		EGF_3	2154..2189	CDD:289699
		EGF_3	2195..2232	CDD:289699
		Link_Domain	2267..2359	CDD:295393
		FAS1	2426..2521	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900