DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta5R2 and PSMB5

DIOPT Version :9

Sequence 1:	NP_001286022.1	Gene:	Prosbeta5R2 / 318924	FlyBaseID:	FBgn0051742	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_002788.1	Gene:	PSMB5 / 5693	HGNCID:	9542	Length:	263	Species:	Homo sapiens

Alignment Length:	244	Identity:	112/244 - (45%)
Similarity:	160/244 - (65%)	Gaps:	14/244 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NMDNPLAIMAPPYENPRESVKKLNALSEVQIDFDHGTTTVGFVYQGGIILCVDSRATSGKLIGSQ 100
            ::.:.|::.||.:..|.|.          .|:..|||||:.|.::.|:|:..|||||:|..|.||
Human    34 SLSDGLSLAAPGWGVPEEP----------GIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQ 88

  Fly   101 SIHKVVQVNQYIMGTTAGGAADCTYWDRALTRECRLHELRYKERLPVQSAAKYISNVAAEYKGMG 165
            ::.||:::|.|::||.|||||||::|:|.|.|:||::|||.|||:.|.:|:|.::|:..:|||||
Human    89 TVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMG 153

  Fly   166 LCMGMMLAGWSPEGPSLVYVDSNGLRIHGKLFAVGSGAPNALGILDSDYRLDLSDNEAYDLAFLA 230
            |.||.|:.||...||.|.||||.|.||.|..|:||||:..|.|::|..|..||...:|||||..|
Human   154 LSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRA 218

  Fly   231 VYHATMTDIFSGGVVRLYHMDQGNWRNVANKDCQELHEQYSGVGNQQTP 279
            :|.||..|.:|||.|.|||:.:..|..|::.:..:|||:|||    .||
Human   219 IYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSG----STP 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta5R2	NP_001286022.1	PTZ00488	46..279	CDD:185666	108/232 (47%)
Prosbeta5R2	NP_001286022.1	proteasome_beta_type_5	72..259	CDD:239730	95/186 (51%)
PSMB5	NP_002788.1	proteasome_beta_type_5	60..247	CDD:239730	95/186 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S454
OMA	1	1.010	-	-		QHG53702
OrthoDB	1	1.010	-	-		D396507at33208
OrthoFinder	1	1.000	-	-		FOG0001305
OrthoInspector	1	1.000	-	-		mtm8519
orthoMCL	1	0.900	-	-		OOG6_100897
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740