DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and KDM4A

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_055478.2	Gene:	KDM4A / 9682	HGNCID:	22978	Length:	1064	Species:	Homo sapiens

Alignment Length:	638	Identity:	275/638 - (43%)
Similarity:	374/638 - (58%)	Gaps:	91/638 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQV 72
            ||..|.||.|||::|.:|:||:||||||:|||||||||.||.||.| |.|:|  ::.|||||.|:
Human    13 RIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRAS-YDDID--DLVIPAPIQQL 74

  Fly    73 VTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGS 137
            |||:.|.:.|.|||||.:||::|.::|::::|.||::.:||:||||||||:|:..|||||||:|:
Human    75 VTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGT 139

  Fly   138 ITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGA 202
            :.:...|.|||.||.||||.|.|:..|.|:||||.|||||||||:|||||||||||||||||||.
Human   140 LYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGE 204

  Fly   203 PKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMI 267
            ||:||.||||.|::||::|..:||.|.::|.|:||||||||||.:||::.:|..|:||||||.||
Human   205 PKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMI 269

  Fly   268 TFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME 332
            |||:|||||||||||||||||||..|||||||:||.|:|..||||||||.||::||.:||.||..
Human   270 TFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKA 334

  Fly   333 GRDVGRHPEDPPNAVLS-AAPLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNV 396
            |:|         |.|:. ..|.|...:.|      |:...|.:|.: :|..|:.|::.::....
Human   335 GKD---------NTVIDHTLPTPEAAEFL------KESELPPRAGN-EEECPEEDMEGVEDGEE- 382

  Fly   397 PDDVKAML-------KESVLTLDTGDLATDEADFPNEDAMSLQ-----SPANL---KTKQELLEY 446
             .|:|..|       |...:.|:.....:....||.||..|.|     .||.|   :.....:..
Human   383 -GDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQ 446

  Fly   447 IDDGTE----DDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRSISPAS- 506
            ::||..    .|..|..|:..|..:..:.|.:::..|:..                |.|::|||
Human   447 VEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAAL----------------DLSVNPASV 495

  Fly   507 ------------STSSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSSA--ATAVKTPTS-AV 556
                        |:||...|:.|...|           .||.|:.|....|  .|.|.|..| |.
Human   496 GGRLVFSGSKKKSSSSLGSGSSRDSIS-----------SDSETSEPLSCRAQGQTGVLTVHSYAK 549

  Fly   557 VAGTTSIATTTTPPADGGGDAKKERQSLQF-------MQQSRKFEGKIPKLSQ 602
            ..|..::....|........:..||:..:.       :::::|.:|:...||:
Human   550 GDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	22/32 (69%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	86/115 (75%)
KDM4A	NP_055478.2	JmjN	13..55	CDD:128818	29/41 (71%)
		JmjC	175..291	CDD:202224	86/115 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..384		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..537		11/46 (24%)
		Interaction with NCOR1. /evidence=ECO:0000269\|PubMed:16024779	597..638		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..641
		PHD_JMJD2A	667..766	CDD:277050
		ePHD_JMJD2A	775..884	CDD:277183
		TUDOR	897..953	CDD:197660
		TUDOR	955..1010	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1496
Isobase	1	0.950	-	0	Normalized mean entropy	S2611
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.800