DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and RPH1

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_011096.1	Gene:	RPH1 / 856916	SGDID:	S000000971	Length:	796	Species:	Saccharomyces cerevisiae

Alignment Length:	862	Identity:	224/862 - (25%)
Similarity:	347/862 - (40%)	Gaps:	242/862 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRS-GYADLDALNVTIPAPICQV 72
            :.||:||:|:|:||..|...:...|. |:|:.||:||.||..:.. .|:......:.|.:||.|.
Yeast    14 VPVFKPTYEQFEDFYAYCKAINKYGM-KSGVVKVIPPKEWKDKLDLPYSAETLQKIKIKSPIQQH 77

  Fly    73 VTGKQGYYQQINIQK-KPLTVKQFSELASTERYATP----------------------KHF---- 110
            ::|.:|.:...|::| |...:.|:.:|  ::.|..|                      |:|
Yeast    78 ISGNKGLFMVQNVEKNKTYNIIQWKDL--SKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSF 140

  Fly   111 ---DFED--------------------LERKYWKNITYVAPIYGADVSGSITDTDQDSWNINRLG 152
               |||.                    ||..|||.:.:..|:||||..|||.....:.||:.:|.
Yeast   141 NIDDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLP 205

  Fly   153 TILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKL 217
            .|||::    ..::.|||.:|||.|:||.:|:||.||.|||||||:||||||.||.:|.|...|.
Yeast   206 NILDHM----ETKVPGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKF 266

  Fly   218 EKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFN 282
            .|...:.||...|||..:|||||.|.||::|:::.:..::|....||.|||:|:|||||||:|:|
Yeast   267 YKFMQEQFPEEAKNCPEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYN 331

  Fly   283 CAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEGRDVGRHPEDPPNAV 347
            .|||.|||:|.|:..||:|.:|.|.:|.|:|.:....|.        |   ||..:..:..|  .
Yeast   332 LAESVNFALEEWLPIGKKAGKCHCISDSVEIDVKKLAKS--------W---RDNNKESKGTP--P 383

  Fly   348 LSAAPLPP----HLDVLLCDKKMKKQCNPTKAKSFKERNPDLD----------------LDEIQQ 392
            |:..|.|.    |...|   |:|       ::.|.:..:||:.                |..::.
Yeast   384 LNQLPNPAMPLLHRPTL---KEM-------ESSSLRSTSPDVGHFSNFKSKSSGVSSPLLSRMKD 438

  Fly   393 NPNVPDDVKAMLKESVLTL-----------------DTGDLA--TDEADFPNEDAMSLQSPAN-- 436
            ..|:   |:..|::..|.|                 :|...|  ||..|  |..||||.|.||
Yeast   439 YSNI---VEPTLEDPTLKLKRISSFQEQPLNKLLKRETSQTAMLTDHED--NIVAMSLTSMANSA 498

  Fly   437 ----------------LKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKT- 484
                            |...|.||                           |..::.||..|..
Yeast   499 ASSPRLPLSRLNSSNELSNAQPLL---------------------------DMTNNTLAFPRPNG 536

  Fly   485 ----------NSRNNRGRS---PRTKDDRSI-------SPASSTSSTSRGARRGKASGTPRKTPA 529
                      :::|..|.|   |.:..:.:|       ||...|.:.||.:.|...:........
Yeast   537 PSGLNPLLYISNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNISRESSRSPIALNYEARQQ 601

  Fly   530 RRKKDSITTSPAVSSAATAVKTPTSAVVAGTTSIATTTTPPADGGGDAKK--ERQSLQFMQQSRK 592
            ..::.|.:|...||:.:|:|..|.|     .|:...|..|.......|.:  :::|.....:|..
Yeast   602 HSQQHSFSTPSTVSNLSTSVLGPLS-----DTNDIKTPHPERPNHKTANRILKKESPVETSKSNL 661

  Fly   593 FEGKIPKLSQTSAAT--GGATAAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIPQQQQQ----- 650
            ...|:....|..:.|  .......:.|:..:|:...::||    |...|.:....:.|::
Yeast   662 ILSKVASTRQEDSFTSRNDDLDKEQGSSPLNSKFAPEEIV----LSGKNKIYICKECQRKFSSGH 722

  Fly   651 ----------------------QQYASTDGNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQ 693
                                  :::...|..:..|..:|.|.:|           :||..:|...
Yeast   723 HLTRHKKSVHSGEKPHSCPKCGKRFKRRDHVLQHLNKKIPCISN-----------ETTVDAPIMN 776

  Fly   694 QQQQQQQQNVATSVAAT 710
            ...|.|....|.:..:|
Yeast   777 PTVQPQDGKAAINQQST 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	14/32 (44%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	63/115 (55%)
RPH1	NP_011096.1	JmjN	13..54	CDD:128818	18/40 (45%)
		JmjC	222..338	CDD:396791	63/115 (55%)
		COG5048	507..>759	CDD:227381	45/287 (16%)
		C2H2 Zn finger	711..732	CDD:275368	1/20 (5%)
		C2H2 Zn finger	740..757	CDD:275368	1/16 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I903
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm9190
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
TreeFam	1	0.960	-	-
	10	9.800