DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and REF6

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_680116.2	Gene:	REF6 / 824002	AraportID:	AT3G48430	Length:	1360	Species:	Arabidopsis thaliana

Alignment Length:	776	Identity:	175/776 - (22%)
Similarity:	279/776 - (35%)	Gaps:	233/776 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSEVPRIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPA 67
            :..:|....||||..||:|...|:..:|.: |.:.|:.|::||   :|..|....:..||.::.|
plant    14 LKSLPVAPEFRPTLAEFQDPIAYILKIEEE-ASRYGICKILPP---LPPPSKKTSISNLNRSLAA 74

  Fly    68 -PICQVVTGKQG------------YYQQINIQKKPLTVKQFSELASTERYATPKHFDFE------ 113
             ...:|..|..|            ..|||....:.....|.....|.|.|:..: |:|:
plant    75 RAAARVRDGGFGACDYDGGPTFATRQQQIGFCPRKQRPVQRPVWQSGEEYSFGE-FEFKAKNFEK 138

  Fly   114 ---------------DLERKYWKNITYVAPI---YGADVSGSI------------------TDTD 142
                           ::|..||: .|...|.   |..|:.||.                  ....
plant   139 NYLKKCGKKSQLSALEIETLYWR-ATVDKPFSVEYANDMPGSAFIPLSLAAARRRESGGEGGTVG 202

  Fly   143 QDSWNINRL----GTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAP 203
            :.:||:..:    |::|.::.:    :|.||.:..:|..|..:.||||.||.||:|:||||.||.
plant   203 ETAWNMRAMSRAEGSLLKFMKE----EIPGVTSPMVYVAMMFSWFAWHVEDHDLHSLNYLHMGAG 263

  Fly   204 KTWYVVPPECGRKLEKVANQYFPASYKN---CNAYLRHKMTLISPQILKQHDVPVSKITQEAGEI 265
            ||||.||.:.....|:|...:......|   ..:.|..|.|::||::..:..:|..::.|..||.
plant   264 KTWYGVPKDAALAFEEVVRVHGYGEELNPLVTFSTLGEKTTVMSPEVFVKAGIPCCRLVQNPGEF 328

  Fly   266 MITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLW 330
            ::|||..||:||:||||..|::|.|...|:...|                |..::|
plant   329 VVTFPGAYHSGFSHGFNFGEASNIATPEWLRMAK----------------DAAIRR--------- 368

  Fly   331 MEGRDVGRHPEDPPNAVLSAAPLPPHLD-----VLLCDKKMKKQCNP--------TKAKSFKER- 381
                           |.::..|:..||.     ||....::....||        .||:|..||
plant   369 ---------------AAINYPPMVSHLQLLYDFVLALGSRVPTSINPKPRSSRLKDKARSEGERL 418

  Fly   382 NPDLDLDEIQQN----------------PNVPDDVKAML-----------KESVLTLDTGDLATD 419
            ...|.:..|..|                |....|:....           :|:.:.|...||::|
plant   419 TKKLFVQNIIHNNELLSSLGKGSPVALLPQSSSDISVCSDLRIGSHLITNQENPIQLKCEDLSSD 483

  Fly   420 E--ADFPNEDAMSLQSPANLKTK-QELLEYIDD---GTEDDDEE--EDFKRRKQ----------- 465
            .  .|..|    .|:...::|.| ..|.|...:   .||.|.:|  .|.:|||.
plant   484 SVVVDLSN----GLKDTVSVKEKFTSLCERSRNHLASTEKDTQETLSDAERRKNDAAVALSDQRL 544

  Fly   466 ----------------------KRRY----DADYDDDWLASKRKTN-SRNNRGRSPRTKDDRSIS 503
                                  ..||    |..:.:||.|:....| .:..|...|::|:...::
plant   545 FSCVTCGVLSFDCVAIVQPKEAAARYLMSADCSFFNDWTAASGSANLGQAARSLHPQSKEKHDVN 609

  Fly   504 -----PASSTS-STSRGARRGKASGTPRKTPARRKKDSI--------TTSPAVSSAATAVKTPTS 554
                 |..:.. |...|.::   :.|...|.|.:..|.:        .:|.:.......:.||:|
plant   610 YFYNVPVQTMDHSVKTGDQK---TSTTSPTIAHKDNDVLGMLASAYGDSSDSEEEDQKGLVTPSS 671

  Fly   555 AVVAGTTSIATTTTPPADGGGDAKKERQSLQFMQQSRKFEGKIPKLSQTSAATGGATAAAE 615
               .|.|.  |.....:||..:|:..|.| .|..|....|       |...:.||.::..|
plant   672 ---KGETK--TYDQEGSDGHEEARDGRTS-DFNCQRLTSE-------QNGLSKGGKSSLLE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	12/32 (38%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	47/118 (40%)
REF6	NP_680116.2	JmjN	21..52	CDD:280526	11/31 (35%)
		JmjC	233..352	CDD:202224	47/118 (40%)
		C2H2 Zn finger	1245..1266	CDD:275368
		C2H2 Zn finger	1268..1290	CDD:275368
		C2H2 Zn finger	1298..1320	CDD:275368
		C2H2 Zn finger	1328..1348	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870