DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and Jade2

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001344517.1	Gene:	Jade2 / 76901	MGIID:	1924151	Length:	901	Species:	Mus musculus

Alignment Length:	278	Identity:	66/278 - (23%)
Similarity:	108/278 - (38%)	Gaps:	56/278 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 DKKMK-----KQCNPTKAKSFKERNPDLDLDEIQQNPNVPDD---VKAMLKESVLTLDTGDLATD 419
            |.|.|     |..:|.|.:..| ..|:..|.::..:.:.|.|   ..:.|.:|| .:...|:|..
Mouse   602 DSKRKGREGPKGSSPEKKEKVK-AGPESVLGQLGLSTSFPIDGTFFNSWLAQSV-QITAEDMAMS 664

  Fly   420 E----ADFPNEDAMSLQSPANLKTKQELLEYI-DDGTEDDDEEEDFKRRKQKRRYDADYDDDWLA 479
            |    :....:.|..|.|...|:.::.||.:: |......|...  |.|.:.|          |.
Mouse   665 EWSLNSGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPAR--KARGRTR----------LP 717

  Fly   480 SKRKTNSRNNRGRSPRTKDDRSISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSS 544
            :|:|.:...: |.|.||..|:  .|..:.:...:|.:     |.|.:.|.||....:.:|||...
Mouse   718 AKKKPSPLQD-GPSARTTPDK--QPKKAWAQDGKGTQ-----GPPMRKPPRRTSSHLPSSPAAGD 774

  Fly   545 A---ATAVKTP--TSAVVAGTTSIATTTTPPADGG-------GDAKKERQSLQFMQQSRKFEGKI 597
            .   ||....|  .|.::..|..:|:.......|.       |..:..|:    |:.|||..|
Mouse   775 CPVPATLESPPPLASEILDKTAPMASDLNVQVPGPTVSPKPLGRLRPPRE----MKVSRKSPG-- 833

  Fly   598 PKLSQTSAATGGATAAAE 615
               :::.|.||..:|.||
Mouse   834 ---ARSDAGTGLPSAVAE 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224
Jade2	NP_001344517.1	EPL1	209..>578	CDD:331339
		ePHD_JADE2	326..436	CDD:277175
		Atrophin-1	<676..852	CDD:331285	49/202 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900