DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and kdm4c

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001077320.1	Gene:	kdm4c / 570194	ZFINID:	ZDB-GENE-070209-38	Length:	1482	Species:	Danio rerio

Alignment Length:	642	Identity:	269/642 - (41%)
Similarity:	360/642 - (56%)	Gaps:	95/642 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQV 72
            :|..||||.||||||.:|:.||||||||:||||||:||..|.|||: |.|:|  :..|.|||.|:
Zfish    15 KIMTFRPTMEEFKDFNQYLVYMESQGAHRAGLAKVIPPKGWKPRRN-YDDID--DFVIQAPIQQM 76

  Fly    73 VTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGS 137
            |.|:.|.:.|.|||||||||::|..||:::.|.||::.::||||||||||:|:|:|||||||||:
Zfish    77 VAGQSGLFTQYNIQKKPLTVQEFRRLANSDMYCTPRYLNYEDLERKYWKNLTFVSPIYGADVSGT 141

  Fly   138 ITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGA 202
            :.|.|.:.|||..|.::||.:.:|..:.|.||||.|||||||||:|:|||||||||||||||||.
Zfish   142 LYDEDIEEWNIGHLNSVLDVIEEDCGVSIQGVNTPYLYFGMWKTSFSWHTEDMDLYSINYLHFGE 206

  Fly   203 PKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMI 267
            ||:||.:|||.|::||::|..:||.|:|:|.|:||||||||||.:||::.:|..||||||||.||
Zfish   207 PKSWYAIPPEHGKRLERLAIGFFPNSFKSCEAFLRHKMTLISPSVLKKYSIPFDKITQEAGEFMI 271

  Fly   268 TFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME 332
            |||:|||||||||||||||||||..|||:|||.|.|||||.||||||||.||:|||.|||:||.:
Zfish   272 TFPYGYHAGFNHGFNCAESTNFASIRWIDYGKLATQCTCSKDMVKISMDPFVRRFQPDRYELWTQ 336

  Fly   333 GRDVGRHPEDPPNAVLSAAPLP---PHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNP 394
            |:|        ..::....|.|   |.|...|..::.|              .|...|
Zfish   337 GKD--------SCSLDHTLPTPSTTPELQSWLQRRRRK--------------TPSTSL------- 372

  Fly   395 NVPDDVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQSPANLKTKQELLEYIDDGTEDDDEEED 459
            :.|......||           ..|.|........|..:....|.|:|             ||||
Zfish   373 HAPRSCSKRLK-----------TVDSAPVKGSGRRSRSAALTAKNKEE-------------EEED 413

  Fly   460 FKRRKQKRRYDAD----------------YDDDWLASKRKTNSRNNRGRSPRTKDDRSISPASST 508
            ..:.:::.:|.::                .:.|.||.    ::|..:..||    :|.::|..:|
Zfish   414 PVKHQKESQYSSELKGLAGRQMCVVKVTRVESDLLAQ----STRQVKEASP----ERLLTPTLTT 470

  Fly   509 SSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSSAATAVKTPTSAVVAGTTSIATTTTPPADG 573
            :|:......|..|..........:....|.|.|.|...:   |..|.::...|..:..|
Zfish   471 TSSQNDPDVGHTSSQTSLILDEGQVSKNTNSTAQSEPES---TSESDIIVDVTLGSERT------ 526

  Fly   574 GGDAKKERQSLQFMQQSRKFEGKIPKLSQTSAATGGATAAAEASTSKSSQGQQQQIV 630
               ||...|:|............||.....:..:.|||.....|.|:.::.:.::.|
Zfish   527 ---AKNPNQTLNCESVLETIAPSIPVTHSLTLHSTGATVLFSESDSQQAKIETEETV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	25/32 (78%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	86/115 (75%)
kdm4c	NP_001077320.1	JmjN	16..57	CDD:128818	29/40 (73%)
		JmjC	177..293	CDD:202224	86/115 (75%)
		PHD_SF	1079..1176	CDD:304600
		ePHD_JMJD2C	1185..1294	CDD:277185
		TUDOR	1308..1364	CDD:197660
		TUDOR	1366..1421	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm6370
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.700