DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and brd1a

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_021327219.1	Gene:	brd1a / 569574	ZFINID:	ZDB-GENE-041008-168	Length:	1142	Species:	Danio rerio

Alignment Length:	793	Identity:	146/793 - (18%)
Similarity:	254/793 - (32%)	Gaps:	250/793 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YVAYMESQGAHKAGLAKVVPP---------PEWVPRRSGYADLDALNVTIPAP------------ 68
            |.|:..| .|.|:||...:.|         |.:..:::.|......|.::..|
Zfish   329 YTAFHVS-CAQKSGLFMKMEPIKVLTDSGIPTFSVKKTAYCGAHTPNGSVKRPLAIYKDNETNYG 392

  Fly    69 ICQVVTGKQ---GYYQQINIQKK---------PLTVKQFSELASTER-------YATPKHFDFED 114
            :||:|..|.   |:.:|..::|.         ||:|..|    |:||       .:..|...|.:
Zfish   393 LCQLVDRKSSRIGFNKQKRLKKNEEAIVTTIPPLSVPSF----SSERLSPILNQVSLQKKTAFGE 453

  Fly   115 LERKYWKNITYVAPIYGADVSGSITDTDQDSWNIN-RLGTILDYVNKDYNIQIDGVNTAYLYFGM 178
            |...||                ::....::...:| ||.|.|.........|.:....|     :
Zfish   454 LVLSYW----------------TLKRQSRNGVPLNRRLQTRLHPPKNSQRKQTEEETQA-----L 497

  Fly   179 WKTTFAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYF------------------ 225
            .:....||....||.....|            .|..||.||:..:..
Zfish   498 KEQLKEWHQLRHDLERARIL------------LELIRKREKLKREEVLLQQTLMEFQLTPFTVIL 550

  Fly   226 ------------------PASYKNCNAYLRHKMTLISPQILKQHDV-PVSKITQEAGEIMITFPF 271
                              |.:.|....|:.|        :|...|. .:||..:..|       :
Zfish   551 RAVLDQLQEKDQAHIFAEPVNIKEVPDYMDH--------VLHPMDFSTMSKRIEAQG-------Y 600

  Fly   272 GYHAGFNHGFNCAESTNFAMERWIEY-GKRAVQCTCSNDMVKISMDTFVKR------------FQ 323
            .|...|...|      |...:..::| ||                |||..|            .:
Zfish   601 KYLDEFEADF------NLITDNCMKYNGK----------------DTFFYRAAVKLRDQGGAILR 643

  Fly   324 SDRYDLWMEGRDV--GRHPEDPPNAVLSAAP----------LPPHLDVLLCDKKMK----KQCNP 372
            ..|.|:...|.|:  |.|..:||. :..:.|          :|.:.:.:..:::::    |....
Zfish   644 KTRRDVQRIGLDLETGLHLLEPPK-IEPSVPFSWEDVDRLLVPANREHMSFEEQLRELLEKLDMT 707

  Fly   373 TKAKSFKERNPDLDLDEIQQNPNVPD-DVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQSPAN 436
            |..||...|:..|.|    ...|:.| .::..|::::..:...:.|.:|....::.. ....|..
Zfish   708 TAMKSSPSRSRRLKL----LKKNISDVRLELSLRKALTAVKLKNAAEEEVGHIHQKG-DKSVPPK 767

  Fly   437 LKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRS 501
            |:....:|..|:  .|...|....|        ..:.:.|..:.::...|::..|.|....:|..
Zfish   768 LEPSVSVLPLIN--AESHSEPPTLK--------PIEPNPDKHSHQKDGISQSLNGDSHLLLEDSD 822

  Fly   502 IS---------PASSTS-STSRGARRGKASGTPRKTPARRKKDSITTSPAVSSAATAVKTPTSAV 556
            |:         |:|..: .||...|:.|:|.:|.:|    .||..|..   .|:....||..|.|
Zfish   823 INVVATSTLAEPSSPVNRRTSVLFRKSKSSTSPLRT----LKDDETLK---GSSQIGTKTFLSVV 880

  Fly   557 VAGTTSIATTTTPPADGGGDAKKERQSLQFMQQSRKFEGKIPKLSQTSAATGGATAAAEAS---- 617
            :....::..|...|....||:.|:             |..:.:|....:.:.|..:..|.|
Zfish   881 IPRLETLLHTRKRPRSASGDSCKD-------------ELPVKRLDTELSNSFGLNSERELSSSSQ 932

  Fly   618 -----TSKSSQGQQQQIVYVNMLPAANTLNGIPQQQQQQQYASTDGNVYQLQNEIL-CDANGHAV 676
                 ||:||.......:.:|:....   .|.|        |....|..:.::||: |..:.:..
Zfish   933 PRQRCTSESSMSSSNSSIALNLTKCG---KGKP--------ALIRRNTVEDKSEIIACIESRNFA 986

  Fly   677 TAATASYQTTASS 689
            .||..:.:..:||
Zfish   987 KAARIAAEVNSSS 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	7/18 (39%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	22/152 (14%)
brd1a	XP_021327219.1	EPL1	83..>555	CDD:331339	48/263 (18%)
		Bromo_brd1_like	545..642	CDD:99944	20/133 (15%)
		BR140_related	1011..1126	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900