Protein Alignment Kdm4B and KDM4D

DIOPT Version :9

• Sequence 1: NP_001260942.1
• Gene: Kdm4B / 318918
• FlyBaseID: FBgn0053182
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_060509.2
• Gene: KDM4D / 55693
• HGNCID: 25498
• Length: 523
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 238/592 - (40%)
• Similarity: 315/592 - (53%)
• Gaps: 141/592 - (23%)

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVV 73
            |.:|.||.|||.||.||:|||||||||:|||||::||.||..|.: |.::.  .:.|..|:.||.
Human    18 IMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARET-YDNIS--EILIATPLQQVA 79

  Fly    74 TGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSI 138
            :|:.|.:.|.:.:||.:||.::..||::::|.||.|.:|||||||||||..|.:||||||:|||:
Human    80 SGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSL 144

  Fly   139 TDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAP 203
            .|.:...||:..||||.|.:.|:..:.|:||||.|||||||||||||||||||||||||||.|.|
Human   145 FDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEP 209

  Fly   204 KTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMIT 268
            |||||||||.|::||::|.:.||.|.:.|.|:||||:.||||.:||::.:|.::|||||||.|:|
Human   210 KTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVT 274

  Fly   269 FPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEG 333
            ||:||||||||||||||:.|||..|||:|||.|.||:|....|..|||.||:..|.:|||||..|
Human   275 FPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRG 339

  Fly   334 RDVGRHPEDPPNAVLSAAPLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPD 398
            :|         .||:.      |::                                   |.||
Human   340 QD---------RAVVD------HME-----------------------------------PRVP- 353

  Fly   399 DVKAMLKESVLTLDTGDLATD-EADFPNEDAMSLQ---------SP----ANLKTKQELLEYIDD 449
                         .:.:|:|. |...|...|:.|:         ||    |...|:...|.
Human   354 -------------ASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLV---- 401

  Fly   450 GTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRSISPASSTSSTSRG 514
                                        .:|..:.::.:.....||.....|....|||.|::.|
Human   402 ----------------------------CSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPG 438

  Fly   515 ----------ARRGKASGTPRKTPARRKKDSITTSPAVSSAATAVKTPTSAVVAGTTSIATTTTP 569
                      .|||:  |.|   |.:.:...:|..       |..|.|   ::||||..|:...|
Human   439 PSAQIIHPSNGRRGR--GRP---PQKLRAQELTLQ-------TPAKRP---LLAGTTCTASGPEP 488

  Fly   570 ---PADG 573
               |.||
Human   489 EPLPEDG 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	24/32 (75%)
		JmjC	173..289	CDD:202224	83/115 (72%)
KDM4D	NP_060509.2	JmjN	19..53	CDD:280526	24/33 (73%)
		JmjC	179..295	CDD:202224	83/115 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..523		27/104 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.770