DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and Jarid2

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	91/440 - (20%)
Similarity:	166/440 - (37%)	Gaps:	74/440 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GYYQQINIQKKPLTVKQFSELASTERYATPKHFD--FEDLERKYWKNIT---------------- 124
            |...:..::.:.:.:.||..:|........|..|  ..::|.::|:::.
  Fly  1952 GVSMECIVKGRSMPLSQFYRIARNTMALWFKSTDPTVNEVEAEFWRHVAVRDSHVCVHSGSIDSS 2016

  Fly   125 ---YVAPIYGADVSGSITDTDQDSWNI----NRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTT 182
               |..|..|....||  :..:..||:    |..|::|..:.     .:.||....|:.||..:.
  Fly  2017 GWGYGFPSPGPKGKGS--NYARHPWNLKVLTNNSGSVLRSLG-----PVMGVTVPTLHVGMLFSA 2074

  Fly   183 FAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQI 247
            ..|:.:...|..|.|||.||.|.||.:|.:.............|...:|...:|.....::.|.:
  Fly  2075 CCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVPPHM 2139

  Fly   248 LKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGK---RAVQCTCSND 309
            |....|.:.:|.|:.||.::.||..|.:....|:..:||..||...|::..|   |.:..:|...
  Fly  2140 LTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESCEPA 2204

  Fly   310 MVKISMDTFV----KRFQSDRYDLWMEGRDVGRHPEDPPNAVLSAAPLPPHLDVLLCDK--KMKK 368
            |..:....|.    :|..|:.....:...:.....|......|.||.: ...:.:..:|  |.||
  Fly  2205 MFSLEQLLFALGYDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGV-TSTEKVQAEKGQKAKK 2268

  Fly   369 QCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQS 433
            |..|    .:|....:.||            .:|.|..|::..:.|::      :..:.|:...:
  Fly  2269 QQQP----PYKSIESECDL------------CRANLYISMVRTEDGNI------YCLQHALKNLN 2311

  Fly   434 PANLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRK 483
            ..|::.||..|.|   ....||.::..::.::|..:.|       |.|:|
  Fly  2312 NGNIQAKQCKLIY---AYNVDDIQQLIRQLQEKINHKA-------AVKKK 2351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	31/115 (27%)
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818
		ARID	1812..1893	CDD:279697
		JmjC	2066..2181	CDD:202224	31/114 (27%)
		zf-C5HC2	2281..2334	CDD:280996	14/73 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940