DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and KDM4E

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001155102.1	Gene:	KDM4E / 390245	HGNCID:	37098	Length:	506	Species:	Homo sapiens

Alignment Length:	335	Identity:	187/335 - (55%)
Similarity:	242/335 - (72%)	Gaps:	5/335 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVV 73
            |..|.||.|||.||..|||||||||||:||||||:||.||..|:. |.|::  ::.|..|:.||.
Human    15 IMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQM-YDDIE--DILIATPLQQVT 76

  Fly    74 TGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSI 138
            :|:.|.:.|.:.:||.:.|.|:..||::::|.||.|.:|.|||::|||:.....||||||:|||:
Human    77 SGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSL 141

  Fly   139 TDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAP 203
            .:.....||:..||||||.:.::..:.|:||||.|||||||||||||||||||||||||||||.|
Human   142 FEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEP 206

  Fly   204 KTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMIT 268
            |||||||||.|:.||::|.:.||...:.|.|:||||:.||||.:||::.:|.:.:||||||.|:|
Human   207 KTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVT 271

  Fly   269 FPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEG 333
            ||:||||||||||||||:.|||..|||:|||.|.||:|....|..|||.||:..|.:.|:||...
Human   272 FPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHR 336

  Fly   334 RDVG--RHPE 341
            :|:.  .|.|
Human   337 QDLAIVEHTE 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	25/32 (78%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	82/115 (71%)
KDM4E	NP_001155102.1	JmjN	16..50	CDD:280526	25/33 (76%)
		JmjC	176..292	CDD:202224	82/115 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.770