DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and Mllt10

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_038951869.1	Gene:	Mllt10 / 361285	RGDID:	1310874	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	103/522 - (19%)
Similarity:	173/522 - (33%)	Gaps:	168/522 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 GFNCAESTNFAMERWIEYGKRAVQC-TCSNDMVKISMDTFVKRFQSDRYDLWMEGRDVGRHPEDP 343
            |..|.|..|.|..  ::|      | .|.....|:...   ||..:..||..:.  |...|.:|.
  Rat   175 GLLCEEEGNGADN--VQY------CGYCKYHFSKLKKS---KRGSNRSYDQSLS--DSSSHSQDK 226

  Fly   344 PNAVLSAAPLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESV 408
            .:..               :||..|:.:..|.|..|:                |:...|::....
  Rat   227 HHEK---------------EKKKYKEKDKHKPKHKKQ----------------PEPSPALVPSLT 260

  Fly   409 LTLDTGDLATDEADFPN-----EDAMSLQSPANLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRR 468
            :|.:....:|.......     ||..:..:.||.   ||:..:...|.:..:...:.|.:|
  Rat   261 VTTEKTYTSTSNNSISGSLKRLEDTAARFTNANF---QEVSAHTSSGKDVSEARSEGKGKK---- 318

  Fly   469 YDADYDDDWLASKRKTNSRNNR---GRSPRTKDDRSISPASSTSSTSRGARRGKASGTPRK---- 526
                      :|...:..|..:   ||:|.|           |.|.|....:|..||||..
  Rat   319 ----------SSAHSSGQRGRKPGGGRNPGT-----------TVSASSPFPQGSFSGTPGSVKSS 362

  Fly   527 --------------TPARRKKDSIT-TSP-----------------AVSSAATAVKTP-TSAVVA 558
                          |.:..:.||.| |.|                 .|:|.::.|..| ||...:
  Rat   363 SGSSVQSPQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNSFSSLVGHPGTSGATS 427

  Fly   559 ------------GTTSIATTTTPPADGGG----DAKKERQSLQFMQQSRKFEGKIPK-------- 599
                        |::|:.|.....|...|    :|.||::. :..:||:...|: ||
  Rat   428 QPKSFDSSPGELGSSSLPTAGYKRAQTSGVEEEEAVKEKKR-KGNKQSKHGPGR-PKGNKNQENV 490

  Fly   600 --LSQTSAATGGATAAAEASTSKSS--------QGQQQQIVYVNMLPAANTLNGIPQQQQQQQYA 654
              ||.:||:...:.|:|..|.:..|        :....|.:.|...|..:.::    .|.:...|
  Rat   491 SHLSVSSASPTSSVASAAGSVTSCSLQKSPTLLRNGSMQSLSVGSSPLGSEIS----MQYRHDGA 551

  Fly   655 STDGNVYQLQNEI---LCDANGHAVT-----AATASYQTTASS--PQQQQQQQQQQQNVATSVAA 709
            .......:|.|.|   :.::|..||:     :.:.|....:||  |||.....||...::.|.|:
  Rat   552 CPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAAS 616

  Fly   710 TI 711
            ::
  Rat   617 SV 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	3/8 (38%)
Mllt10	XP_038951869.1	PHD_AF10_AF17	24..71	CDD:277049
		ePHD_AF10	78..206	CDD:277178	9/41 (22%)
		CC_AF10	717..780	CDD:411015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900