DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and CG15439

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_608836.1	Gene:	CG15439 / 33651	FlyBaseID:	FBgn0031606	Length:	1008	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	138/749 - (18%)
Similarity:	222/749 - (29%)	Gaps:	292/749 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 HKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVVTGKQGYYQQINIQKKPLTVKQFSELA 99
            ||....|.:.|..|||.:.    :..| :|..|..|:.:..|                   :|:.
  Fly   354 HKYTRHKELKPTPWVPTQK----MSRL-LTTSASACRRLLAK-------------------AEIM 394

  Fly   100 STERYATPKHFDFEDLE------------RKYWKNITYVAPIYGADVSGSITDTDQDSWNINRLG 152
            |.         |.:.||            ||.|    ::||.:..:.:         ::.::|:.
  Fly   395 SV---------DVQHLEQREAHINALTDIRKKW----HIAPAFSVEFT---------AYYMDRIV 437

  Fly   153 TILDY-------------VNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHF---- 200
            .:.|:             ::||.::.....:||     :.:......|:|..|.||..||.
  Fly   438 RMDDFRQQQRELISHNAILSKDQDVLRAQYDTA-----LEERKAVKATKDSLLTSIKSLHTALGQ 497

  Fly   201 -------------------GAPKTWYVVPPECGRKLEKVA----NQYFPASYKNCNAYLRHKMTL 242
                               ..|||....||:....:...|    ...||..:............:
  Fly   498 IAPNMTLPSVDLIAHPLPEAPPKTSTPTPPQRPISVPTAAALKMGVGFPLGHLGPPGSKMDSSRM 562

  Fly   243 ISPQILKQHDVPVSKITQEAG--------------EIMI---TFPFGYHAGF------------- 277
            :|.. .||.....|..:.||.              .:::   |....||.|.
  Fly   563 LSTH-AKQGKHSTSSASVEAAPSVSCGICKRSKDQHLLVKCDTCNLHYHLGCLNPPLTRPPKKSK 626

  Fly   278 NHGFNC------AESTNFAMERWIEYGKRAVQCTCSND--MVKISMDTFVKRFQSDRYDLWMEGR 334
            .:|:.|      :|.::...|  |..|.|..:...:.|  :|.:           |||.|
  Fly   627 QYGWQCSECCDKSEGSDAVTE--ISSGPRKSRTRFNKDGHLVYV-----------DRYSL----- 673

  Fly   335 DVGRHPEDPPNAVLSA---------------APLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPD 384
                  :|.|.|.::.               ||.|.:::.|....|..|..:|.|...
  Fly   674 ------DDIPVAAVNVPKESHTKRALNKSLPAPAPEYIEDLTKSPKRPKLQSPCKTPI------- 725

  Fly   385 LDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQSPA---NLKTKQELL-- 444
                      |||       .|:|..      .||.|..    |.|..:||   .|.|...::
  Fly   726 ----------NVP-------AENVTP------TTDAAPV----AASAATPAAAPTLPTPNTIVIN 763

  Fly   445 -----EYIDDGT-------------------EDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTN 485
                 :.|||.:                   ..|.|:...|..|:||:..|..|:   :|....|
  Fly   764 LSGCEDSIDDSSGKLSRKGKRKDKHKNKHNLSSDTEKSIGKEHKRKRKKRAHLDE---SSTHLDN 825

  Fly   486 SRNNRG----------RSPRTKDDRS---ISPASSTSSTSRGARRGKASGTPRKTPARRKKDSI- 536
            :.|..|          |.|......|   ..||::..|....:         |.|.....:||:
  Fly   826 AGNTSGSTIKIIFKALRLPGEDAPESQYFYVPANAVRSVDEAS---------RPTSVETVEDSVQ 881

  Fly   537 ----TTSPAVSSAATAVKTPTSAVVAGTTSIATTTTPPADGGGDAKKERQSLQFMQQSRKFEGKI 597
                ..:|.|..||:..|.......|.:.|:..|.:|         |.:.|      .||...:.
  Fly   882 GAEQALAPIVLPAASPQKVREPKETAASASVNPTPSP---------KRKVS------PRKASPRK 931

  Fly   598 PKLSQTSAATGGATAAAEASTSKSSQ-GQQQQIV 630
            |::.:...:  .|....|.|....|| |:..|:|
  Fly   932 PRVGRPRVS--NAKPNVEISCCVCSQTGKSNQVV 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	3/8 (38%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	28/178 (16%)
CG15439	NP_608836.1	PHD1_PHF14	120..175	CDD:277036
		ePHD_PHF14	184..297	CDD:277144
		PHD2_PHF14	586..635	CDD:277037	6/48 (13%)
		PHD3_PHF14	949..997	CDD:277038	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900