DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and kdm4ab

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_001339664.2	Gene:	kdm4ab / 334347	ZFINID:	ZDB-GENE-030131-6279	Length:	1045	Species:	Danio rerio

Alignment Length:	649	Identity:	278/649 - (42%)
Similarity:	367/649 - (56%)	Gaps:	106/649 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVP---RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTI 65
            |::|   .|..|.||.||||:|.:|:|||||||||||||||:|||..|.||.| |.|:|  ::.|
Zfish     3 SDMPVSRGIMTFHPTVEEFKNFSRYIAYMESQGAHKAGLAKIVPPKNWKPRGS-YDDID--DLII 64

  Fly    66 PAPICQVVTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIY 130
            ||||.|||||:.|.:.|.|||||.:|||:|.:.|:::::.:|::.|||:||||||||:|:..|||
Zfish    65 PAPIQQVVTGQSGLFTQYNIQKKAMTVKEFRKTANSDKFCSPRYDDFEELERKYWKNVTFNPPIY 129

  Fly   131 GADVSGSITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSI 195
            ||||:|::.|.|...||:..|.||||.|..:..|.|:||||.|||||||||||||||||||||||
Zfish   130 GADVNGTLYDPDIKEWNVGHLNTILDTVEHESGITIEGVNTPYLYFGMWKTTFAWHTEDMDLYSI 194

  Fly   196 NYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQ 260
            ||||||.||:||.||||.|::||::|..:||.|.:||.|:||||||||||.|||::.:|..||||
Zfish   195 NYLHFGEPKSWYTVPPEHGKRLERLAKGFFPGSSQNCEAFLRHKMTLISPSILKKYGIPFEKITQ 259

  Fly   261 EAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSD 325
            ||||.|:|||:|||||||||||||||||||..|||:|||:|:.|:|..||||||||.|||:||.:
Zfish   260 EAGEFMVTFPYGYHAGFNHGFNCAESTNFATRRWIDYGKQAILCSCRKDMVKISMDVFVKKFQPE 324

  Fly   326 RYDLWMEGRDVGRHPEDPPNAVLS-AAPLPPHLDVL-----LCDKKMKKQCNPTKAKSF------ 378
            ||:||:||:|         ||.:. :.|.|...:.|     ..:.:::.|.|..:.||.
Zfish   325 RYELWLEGKD---------NAPIDHSKPTPEAAEFLGGEAGAQELRIENQSNEGQKKSLAKQRIG 380

  Fly   379 -KERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNED-AMSLQSPANLKTKQ 441
             |.....||..|........:|.....|:..||..| :...:..:..:|| .:.|....:||
Zfish   381 TKRHRVCLDFPEEVLPKTETNDEAEYGKKGRLTPYT-EQCKEYTELKHEDRTLPLMGSTSLK--- 441

  Fly   442 ELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRSISPAS 506
                 :..|:...:..|:.:.....   |||.|       .|..|..:....|..|...||:...
Zfish   442 -----MLPGSRSAEFSENVRGAGFS---DADLD-------AKATSHISACAQPFPKHHLSIASVP 491

  Fly   507 STSSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSS------------------AATAV---- 549
            :....        .|..||          ::|.|.|:|                  ||.|.
Zfish   492 TVPHC--------LSAVPR----------VSTKPGVASLLFHRTLSPTDALQVHSYAAKAALCKP 538

  Fly   550 KTPTSAVVAGTTSI--------ATTTTPPADGGG---DAKKERQSLQFMQQSRKFE--GKIPKL 600
            :||:.........|        ..|.|||.|...   :.:||..|::     ||.:  .|:|:|
Zfish   539 QTPSPEKPREDLHIPDISLDVRPNTPTPPPDTPEHEIEGEKENNSMK-----RKLQPLSKLPRL 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	24/32 (75%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	89/115 (77%)
kdm4ab	XP_001339664.2	JmjN	10..52	CDD:128818	29/41 (71%)
		JmjC	172..288	CDD:202224	89/115 (77%)
		PHD_SF	654..746	CDD:304600
		ePHD_JMJD2A	755..864	CDD:277183
		TUDOR	879..932	CDD:197660
		TUDOR	936..991	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578737
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm6370
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730