DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and Jade2

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_038941852.1	Gene:	Jade2 / 303113	RGDID:	1309152	Length:	901	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	72/294 - (24%)
Similarity:	102/294 - (34%)	Gaps:	88/294 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 DKKMK-----KQCNPTKAKSFKERNPDLDLDEIQQNPNVPDD---VKAMLKESVLTLDTGDLATD 419
            |.|.|     |..:|.|.:..| ..|:..|.::..:.:.|.|   ..:.|.:|| .:...|:|..
  Rat   602 DSKRKGREGPKGSSPEKKEKMK-AGPESVLGQLGLSTSFPIDGTFFNSWLAQSV-QITAEDMAMS 664

  Fly   420 EADFPNEDAMSLQS-----PANLKTKQELLEYIDDGTEDDDEEE--DFKRRKQKRRYDADYDDDW 477
            |        .||.|     ||.....:|||:         |||.  .|.|....|..|.
  Rat   665 E--------WSLNSGHREDPAPGLLSEELLQ---------DEETLLSFMRDPSLRPGDP------ 706

  Fly   478 LASKRKTNSRNNRGRS--------PRTKDDRSISPASSTSSTSRGARRGKAS-GTPRKTPARRKK 533
                    :|..|||:        |..:|..|........:....|:.||.: |.|.:.|.||..
  Rat   707 --------ARKARGRTRLPAKKKPPPLQDGPSARTTPEKPAKKAWAQDGKGTQGPPARKPPRRTS 763

  Fly   534 DSITTSPAVSSA---ATAVKTPTSAVVAGTTSIATTTTPPADG------G--------GDAKKER 581
            ..:.:|||....   ||....||.|     :.|...|.|.|..      |        |..:..|
  Rat   764 SHLPSSPAAGDCPVPATLESPPTLA-----SEILDETVPAASDLNVQVPGPTVSPKPLGRLRPPR 823

  Fly   582 QSLQFMQQSRKFEGKIPKLSQTSAATGGATAAAE 615
            :    |:.|||..|     :::.|.||..:..||
  Rat   824 E----MKVSRKSPG-----ARSDAGTGLPSTVAE 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224
Jade2	XP_038941852.1	EPL1	82..247	CDD:402235
		COG5141	209..>578	CDD:227470
		PHD_SF	326..436	CDD:419867
		PHA03247	<676..852	CDD:223021	52/210 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900