DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and Kdm4c

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001100133.3	Gene:	Kdm4c / 298144	RGDID:	1307528	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	256/534 - (47%)
Similarity:	330/534 - (61%)	Gaps:	103/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQV 72
            :|..|||:.|||::|.||:|||||:|||:||||||:||.||.||:. |.|:|  |:.|||||.|:
  Rat    15 KIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC-YDDID--NLLIPAPIQQM 76

  Fly    73 VTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGS 137
            |||:.|.:.|.||||||:|||:|.:||::.:|.||::.|:||||||||||:|:||||||||::||
  Rat    77 VTGQSGLFTQYNIQKKPMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGS 141

  Fly   138 ITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGA 202
            |.|...|.|||.||.|:||.|.::..|.|:||||.|||||||||||||||||||||||||||||.
  Rat   142 IYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGE 206

  Fly   203 PKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMI 267
            ||:||.:|||.|::||::|..:||:|.:.|:|:||||||||||.:||::.:|..||||||||.||
  Rat   207 PKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMI 271

  Fly   268 TFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME 332
            |||:|||||||||||||||||||..|||:|||.|..|||.|||||||||.|||:||.|||.:|.:
  Rat   272 TFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQ 336

  Fly   333 GRDVGR--H----PEDPPNA------------------------------------------VLS 349
            |:|:..  |    ||..|..                                          |.|
  Rat   337 GKDIYTIDHTKPTPESTPEVKTWLQRRKKLRKAPKSLQGNKSLSKRPKAEEDEEFAEFIGEEVSS 401

  Fly   350 AAPLPPHLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDV----KAMLKESVLT 410
            .|..|.||.|  .:|..|.:.....|.|.||.:.    ..||.:.::.:|.    |:.:..||:
  Rat   402 PAVCPRHLKV--TEKPEKFKLANIGASSEKEASD----TRIQVDQSLTNDTKLSGKSCINSSVI- 459

  Fly   411 LDTGDLATDEADFPNEDAMSLQSPANLKTKQELLEY----------------------------- 446
                    ||....|:.|.::.||:.||...:|:.:
  Rat   460 --------DEIQPENDTANAVTSPSTLKKASDLIPFSHGHITGKESRLLKILQLESPKIPSSLAE 516

  Fly   447 ----IDDGTEDDDE 456
                :.:|.|:|:|
  Rat   517 SNRVLTEGEENDEE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	23/32 (72%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	87/115 (76%)
Kdm4c	NP_001100133.3	JmjN	16..57	CDD:301729	28/40 (70%)
		JmjC	177..293	CDD:202224	87/115 (76%)
		PHD_SF	642..743	CDD:304600
		PHD_SF	752..861	CDD:304600
		TUDOR	874..930	CDD:197660
		TUDOR	932..987	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339148
Domainoid	1	1.000	210	1.000	Domainoid score	I2717
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm9003
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.790