DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and Kdm4d

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_775609.2	Gene:	Kdm4d / 244694	MGIID:	3606484	Length:	510	Species:	Mus musculus

Alignment Length:	523	Identity:	234/523 - (44%)
Similarity:	304/523 - (58%)	Gaps:	75/523 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVV 73
            |.:||||.|||.||.||:|||||||||:||||||:||.||..|:| |.::.  |:.|..|:.|||
Mouse    15 IMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQS-YDNIS--NILIATPLQQVV 76

  Fly    74 TGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSI 138
            :|:.|.:.|.:.:||.:||.::.|||::::|.||.|.||||||||||||..|.:||||||||||:
Mouse    77 SGQAGVFTQYHKKKKGMTVGEYRELANSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSL 141

  Fly   139 TDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAP 203
            .|.....||:..||||.|.:.::..|.|:||||.|||||||||||||||||||||||||||||.|
Mouse   142 FDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQP 206

  Fly   204 KTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMIT 268
            ||||.||||.||:||::|.:.||.|.:.|.|:||||:.||||.:||::.:|..:|||||||.|:|
Mouse   207 KTWYAVPPEHGRRLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVT 271

  Fly   269 FPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEG 333
            ||:||||||||||||||:.|||..|||:|||.|.||:|....|..|||.||:..|.:||:||..|
Mouse   272 FPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYELWKRG 336

  Fly   334 RDVGRHPEDPPNAVLSAAPLPPHLDVLLCDKKMKKQCNPTKA-------KSFKERNPDLDLDEIQ 391
            :|         .||:.      |.:.::...:.......|||       |..:.|.....|..|.
Mouse   337 QD---------QAVVD------HTETMVSTSQELTTRRVTKAPRKTWGLKRLRLRQVSRSLLPIA 386

  Fly   392 QNPNV------------PDDVKAMLKESVLTLDTGDLATDEADFPNEDAMSLQSPANLKTKQELL 444
            ...||            |.|||.           .|:...::...:...:||.|..::.|
Mouse   387 TVSNVPCNMQVCHTSRQPSDVKG-----------DDVQKSDSARASPHPLSLPSSGHMST----- 435

  Fly   445 EYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRSISPASSTS 509
                             ||....|...:     |.::..:|....:.:.|..:||.|.||.....
Mouse   436 -----------------RRCSLGRRPCE-----LGAQESSNGAPVKRQLPAGRDDTSPSPELQPQ 478

  Fly   510 STS 512
            :.|
Mouse   479 AVS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	26/32 (81%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	84/115 (73%)
Kdm4d	NP_775609.2	JmjN	15..55	CDD:128818	30/39 (77%)
		JmjC	176..292	CDD:334913	84/115 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..510		21/123 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2810
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1649
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8759
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820