DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and JADE2

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001276914.1	Gene:	JADE2 / 23338	HGNCID:	22984	Length:	850	Species:	Homo sapiens

Alignment Length:	305	Identity:	68/305 - (22%)
Similarity:	107/305 - (35%)	Gaps:	73/305 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 HLDVLLCDKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDE 420
            ||.:.|.::.:.::.:..:||..|..:.....:..:.:....:.|||. .:|||    |.||...
Human   521 HLQMKLIEQDLCRERSGRRAKGKKSDSKRKGCEGSKGSTEKKEKVKAG-PDSVL----GQLAGLS 580

  Fly   421 ADFPNED-------AMSLQSPANLKTKQELLEY-IDDGTEDD------------DEEE--DFKRR 463
            ..||.:.       |.|:|..|.   ...:.|: :::|..:|            |||.  .|.|.
Human   581 TSFPIDGTFFNSWLAQSVQITAE---NMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRD 642

  Fly   464 KQKRRYDADYDDDWLASKRKTNSRNNRGRSP-----------RTKDDRSISPASSTSSTSRGARR 517
            ...|..|.       |.|.:..:|....:.|           ||..|::   ...|.....|:.:
Human   643 PSLRPGDP-------ARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKA---PKKTWGQDAGSGK 697

  Fly   518 GKASGTPRKTPARRKKDSITTSPAV----------SSAATAVKTPTSAVVAGTTSIATTTTPPAD 572
            | ..|.|.:.|.||....:.:|||.          |....|.:||..|......|......|.|.
Human   698 G-GQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAAS 761

  Fly   573 GG--GDAKKERQSLQFMQQSRKFEGKIPKLSQTSAATGGATAAAE 615
            ..  |..:..|:|    :.:|:..|..|     .|..|..:|.||
Human   762 PKPLGRLRPPRES----KVTRRLPGARP-----DAGMGPPSAVAE 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224
JADE2	NP_001276914.1	EPL1	<153..191	CDD:287484
		PHD_JADE2	217..262	CDD:277150
		ePHD_JADE2	270..380	CDD:277175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900