DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and KDM4C

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001340926.1	Gene:	KDM4C / 23081	HGNCID:	17071	Length:	1089	Species:	Homo sapiens

Alignment Length:	679	Identity:	293/679 - (43%)
Similarity:	393/679 - (57%)	Gaps:	121/679 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKMSEVP-------RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADL 58
            |:::||.       :|..|||:.|||::|.||:|||||:|||:||||||:||.||.||:. |.|:
Human     1 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC-YDDI 64

  Fly    59 DALNVTIPAPICQVVTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNI 123
            |  |:.|||||.|:|||:.|.:.|.|||||.:|||:|.:||::.:|.||::.|:||||||||||:
Human    65 D--NLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNL 127

  Fly   124 TYVAPIYGADVSGSITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTE 188
            |:||||||||::|||.|...|.|||.||.|:||.|.::..|.|:||||.||||||||||||||||
Human   128 TFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTE 192

  Fly   189 DMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDV 253
            |||||||||||||.||:||.:|||.|::||::|..:||:|.:.|:|:||||||||||.:||::.:
Human   193 DMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGI 257

  Fly   254 PVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTF 318
            |..||||||||.|||||:|||||||||||||||||||..|||:|||.|..|||..||||||||.|
Human   258 PFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIF 322

  Fly   319 VKRFQSDRYDLWMEGRDVGR--HPEDPPNAVLSAAPLPPHLDVLLCDKKMKK-----QCNPTKAK 376
            |::||.|||.||.:|:|:..  |.:..|      |..|.....|...:|::|     ||    |:
Human   323 VRKFQPDRYQLWKQGKDIYTIDHTKPTP------ASTPEVKAWLQRRRKVRKASRSFQC----AR 377

  Fly   377 SFKERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNEDA------MSLQSPA 435
            |..:| |..|.:|     .|.|:|                  |.|:.||.|:      :|.:|.|
Human   378 STSKR-PKADEEE-----EVSDEV------------------DGAEVPNPDSVTDDLKVSEKSEA 418

  Fly   436 NLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNS--RNNRGRSPRTKD 498
            .:|.:         .||...|||....|.|..:..:|:      .|...||  ..:.....:|:|
Human   419 AVKLR---------NTEASSEEESSASRMQVEQNLSDH------IKLSGNSCLSTSVTEDIKTED 468

  Fly   499 DRSISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTS-----PAVS--SAATAVKTPTSAV 556
            |::.:..|..|.:|..                  .|||..|     |..|  |..:..|:|.|.
Human   469 DKAYAYRSVPSISSEA------------------DDSIPLSSGYEKPEKSDPSELSWPKSPESC- 514

  Fly   557 VAGTTSIATTTTPPADG-GGDAKKERQSLQFMQQSRKFEGKIPKL--SQTSAATGGATAAAEAST 618
                :|:|.:.....:| ..|.:.....|:        .|:||.:  .:.::....:.|..|..|
Human   515 ----SSVAESNGVLTEGEESDVESHGNGLE--------PGEIPAVPSGERNSFKVPSIAEGENKT 567

  Fly   619 SKSSQGQQQQIVYVNMLPAANTLNGIPQQ 647
            |||.:..      ::..||.:.:..:.||
Human   568 SKSWRHP------LSRPPARSPMTLVKQQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	23/32 (72%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	87/115 (76%)
KDM4C	NP_001340926.1	JmjN	16..57	CDD:326657	28/40 (70%)
		JmjC	177..293	CDD:202224	87/115 (76%)
		PHD_JMJD2C	644..746	CDD:277052
		ePHD_JMJD2C	755..864	CDD:277185
		TUDOR	912..966	CDD:197660
		TUDOR	968..1023	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145456
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1496
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.680