DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kdm4B and KDM4B

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens

Alignment Length:	734	Identity:	292/734 - (39%)
Similarity:	378/734 - (51%)	Gaps:	161/734 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQV 72
            :|..||||.||||||.|||||:||||||:|||||::||.||.||:: |.|:|  :|.|||||.||
Human    14 KIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQT-YDDID--DVVIPAPIQQV 75

  Fly    73 VTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGS 137
            |||:.|.:.|.|||||.:||.::..||::|:|.||:|.||:|||||||||:|:|:||||||:|||
Human    76 VTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGS 140

  Fly   138 ITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGA 202
            :.|.|...|||..|.||||.|.::....|:||||.|||||||||||||||||||||||||||||.
Human   141 LYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGE 205

  Fly   203 PKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMI 267
            ||:||.:|||.|::||::|..:||.|.:.|:|:||||||||||.|||::.:|.|:|||||||.||
Human   206 PKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI 270

  Fly   268 TFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME 332
            |||:|||||||||||||||||||..|||:|||.|.||||..||||||||.||:..|.:||:||.:
Human   271 TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQ 335

  Fly   333 GRDVGRHPEDPPNAVLSAAPLPPHLD------VLLCDKKMKKQC----NPTKAKSFKERNPDLDL 387
            |:|:.......|.|:.|     |.|.      ..|..|.:::|.    |....|:.:||.|.|:.
Human   336 GKDLTVLDHTRPTALTS-----PELSSWSASRASLKAKLLRRQISLKENRHWRKTEEERKPSLER 395

  Fly   388 DEIQ-QNPNV-------------PDDVKAMLKESVLTLDTGDLATDEADFPNED--AMSLQSPAN 436
            .:.| :.|.:             |:|.|                     ||.|.  ..:|...|.
Human   396 KKEQTKRPGLSSHRKRSQPKKPKPEDPK---------------------FPGEGTAGAALLEEAG 439

  Fly   437 LKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRS 501
            ...|:|.      |.|.|.|||:.:.:...                       .||.
Human   440 GSVKEEA------GPEVDPEEEEEEPQPLP-----------------------HGRE-------- 467

  Fly   502 ISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTSPA---------VSSAATAVKTPTSAVV 557
               |.......||..|      |.|..:.|||.|....|.         .|..|..:.:|....|
Human   468 ---AEGAEEDGRGKLR------PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPV 523

  Fly   558 AGTTSIATTTTP-------------------------------PADGGGDAKKERQSLQ-----F 586
            .|....|...:|                               |..|.....:|..|.|     |
Human   524 LGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHF 588

  Fly   587 MQQSRKFEGKIPKLSQTSAATGGATAAAEASTSKSSQGQQQQIVYVNML---------------P 636
            .|:...::..:..:..|....|.|::.|....:|:..|:.|.....:.|               |
Human   589 AQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPP 653

  Fly   637 AANTLNGIPQQQQQQQYAS 655
            ..:.|:.:.|:....:.||
Human   654 TRSPLSVVKQEASSDEEAS 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	26/32 (81%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	88/115 (77%)
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818	31/40 (78%)
		JmjC	176..292	CDD:202224	88/115 (77%)
		PHD_JMJD2B	717..822	CDD:277051
		ePHD_JMJD2B	831..940	CDD:277184
		TUDOR	955..1007	CDD:197660
		TUDOR	1009..1064	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1496
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750