DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and jmjd-2

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_496969.2	Gene:	jmjd-2 / 175080	WormBaseID:	WBGene00012982	Length:	922	Species:	Caenorhabditis elegans

Alignment Length:	332	Identity:	154/332 - (46%)
Similarity:	211/332 - (63%)	Gaps:	16/332 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAH-KAGLAKVVPPPEWVPR--RSGYADLDALNVTIPAPIC 70
            :..|.||..|||:|.:|:..:|..|.| |||:||:|.|..|.||  |..::|:|...:|.||...
Worm    87 VLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEITQPARET 151

  Fly    71 QVVTGKQGYYQQINIQ-KKPLTVKQFSELASTERYATPK-HFDFEDLERKYWKNITYVAPIYGAD 133
            ...|.|.|.|.:.|:. ::.:.|::|..||::.:|..|: .....::|:.|:.||.:..||||||
Worm   152 IEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHGEPIYGAD 216

  Fly   134 VSGSITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYL 198
            ..||..|...:.||:|||||||:    |.|.:|.||||.||||||:||||.||.|||||||||:|
Worm   217 TEGSFYDAQVEEWNMNRLGTILE----DTNYEIKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFL 277

  Fly   199 HFGAPKTWYVVPPECGRKLEKVANQYFPASYKN-----CNAYLRHKMTLISPQILKQHDVPVSKI 258
            ||||||.|:.:..|...:.|:..:|.|  ||:|     |.|:||||..|::|::|:|..:|.:.:
Worm   278 HFGAPKYWFAISSEHADRFERFMSQQF--SYQNEYAPQCKAFLRHKTYLVTPELLRQAGIPYATM 340

  Fly   259 TQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQ 323
            .|...|.:||||.|||.|||.|:|.|||||||.:|||:|||.||.|.|:.|.|||.|..|:.:::
Worm   341 VQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDCNKDSVKIDMTHFMAKYR 405

  Fly   324 SDRYDLW 330
            .|.|..|
Worm   406 PDEYTTW 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526	16/33 (48%)
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	65/120 (54%)
jmjd-2	NP_496969.2	JmjN	86..129	CDD:128818	19/41 (46%)
		JmjC	252..371	CDD:202224	65/120 (54%)
		PHD_SF	536..603	CDD:304600
		PHD_SF	588..629	CDD:304600
		ePHD	642..782	CDD:277046
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158570
Domainoid	1	1.000	147	1.000	Domainoid score	I2771
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2611
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		otm14681
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680