DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and Mllt10

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_006497436.2	Gene:	Mllt10 / 17354	MGIID:	1329038	Length:	1101	Species:	Mus musculus

Alignment Length:	434	Identity:	91/434 - (20%)
Similarity:	156/434 - (35%)	Gaps:	125/434 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 DKKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPN-- 425
            ||..:|:     .|.:||::     ...|::...|:...|::....:|.:....:|.......
Mouse   225 DKHHEKE-----KKKYKEKD-----KHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSL 279

  Fly   426 ---EDAMSLQSPANLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSR 487
               ||..:..:.||.   ||:..:...|  .|..|......|.|              |...:|.
Mouse   280 KRLEDTAARFTNANF---QEVSAHTSSG--KDVSEARGSEGKGK--------------KSSAHSS 325

  Fly   488 NNRGRSPRTKDDRSISPASSTSSTSRGARRGKASGTPRK------------------TPARRKKD 534
            ..|||.|    ....:|.::.|::| ...:|..||||..                  |.:..:.|
Mouse   326 GQRGRKP----GAGRNPGTAVSASS-PFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSD 385

  Fly   535 SIT------------------TSPAVSSAATAVKTP-TSAVVA------------GTTSIATTTT 568
            |.|                  ...||:|.::.|..| ||.|::            |::|:.|...
Mouse   386 SYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGY 450

  Fly   569 PPADGGG---DAKKERQSLQFMQQSRKFEGKIPK----------LSQTSAATGGATAAAEASTSK 620
            ..|...|   :|.||::. :..:||:...|: ||          ||.:||:...:.|:|..|.:.
Mouse   451 KRAQTSGIEEEAVKEKKR-KGNKQSKHGPGR-PKGNKNQENVSHLSVSSASPTSSVASAAGSVTS 513

  Fly   621 SS--------QGQQQQIVYVNMLPAANTLNGIPQQQQQQQYASTDGNVYQLQNEI---LCDANGH 674
            ||        :....|.:.|...|..:.::    .|.:...|.......:|.|.|   :.::|..
Mouse   514 SSLQKSPTLLRNGSLQSLSVGSSPVGSEIS----MQYRHDGACPTTTFSELLNAIHNGIYNSNDV 574

  Fly   675 AVT-----AATASYQTTASS--PQQQQQQQQQQQNVATSVAATI 711
            ||:     :.:.|....:||  |||.....||...::.|.|:::
Mouse   575 AVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSV 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224
Mllt10	XP_006497436.2	PHD_AF10_AF17	24..71	CDD:277049
Mllt10	XP_006497436.2	ePHD_AF10	78..206	CDD:277178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900