Protein Alignment Kdm4B and KDM4F

DIOPT Version :10

• Sequence 1: NP_001260942.1
• Gene: Kdm4B / 318918
• FlyBaseID: FBgn0053182
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001400684.1
• Gene: KDM4F / 100129053
• HGNCID: 52413
• Length: 638
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 239/690 - (34%)
• Similarity: 326/690 - (47%)
• Gaps: 172/690 - (24%)

  Fly     9 IKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQVV 73
            |..|.||.|||.||..|||||||||||:||||||:||.||..|:. |.|::  ::.|..|:.||.
Human    15 IMTFYPTMEEFADFNTYVAYMESQGAHRAGLAKVIPPKEWKARQM-YDDIE--DILIATPLQQVT 76

  Fly    74 TGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSI 138
            :|:.|.:.|.:.:||.:.|.|:..||::::|.||.|.:|.|||::|||:.....||||||:|||:
Human    77 SGQGGVFTQYHKKKKAMRVGQYRHLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSL 141

  Fly   139 TDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAP 203
            .:.....||:..||||||.:.::..:.|:||||.|||||||||||||||||||||||||||||.|
Human   142 FEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEP 206

  Fly   204 KTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMIT 268
            |||||||||.|::||.:|.:.||.:.:.|..:||||:.||||.:||::.:|.:::||||||.|:|
Human   207 KTWYVVPPEHGQRLECLARELFPGNSRGCEGFLRHKVALISPTVLKKNGIPFNRMTQEAGEFMVT 271

  Fly   269 FPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWMEG 333
            ||:||||||||||||||:.|||..|||:|||.|.||:|....|..|||.||:..|.:.|:||...
Human   272 FPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVTFSMDAFVRILQPESYELWKHR 336

  Fly   334 RDVG---------RHPEDPPN---------AVLSAAPLPPHLDVLLCDKKMKKQCNPTKAKSFKE 380
            :|:.         ...::|.|         |.|....|..|:          ..| ||:..:
Human   337 QDLTVVDYMEPRVAESQEPSNWREDIALRRAALGLRHLRNHI----------TSC-PTRTVA--- 387

  Fly   381 RNPDLDLDEIQQNPN------VPDDVKAMLKES--VLTLDTGDLATDEADFPNEDAMSLQSPANL 437
                   ..:..||.      ||......|:.|  ||...||
Human   388 -------PRLCYNPKGGGTDAVPGSAIQALETSAWVLPPSTG----------------------- 422

  Fly   438 KTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASK---RKTNSRNNRGRSPRTKDD 499
                                                  .|...:   |.......|||.||
Human   423 --------------------------------------RWGPCRGCGRGRGRGRGRGRRPR---- 445

  Fly   500 RSISPASSTSSTSRGARRGKASGTPRKTPARRKK-----DSITTSPAVSSAATAVKTPTSAV--- 556
               ...:..::....|:|..:.||..:.|.|:.:     :::|..||..|.........|..
Human   446 ---ELGTEETTVQSAAKRRLSVGTGSRAPGRKPQLQFADEALTDKPAPLSGGLPHFAKASGCCCA 507

  Fly   557 ---------------------------VAGTTSIATTTTPPA----------DGGGDAKKERQSL 584
                                       .|.:..:....|||:          |.|||.|......
Human   508 PDLQPLGPPLDPDEPMHPGPCLLSLDSTASSLPLVVPMTPPSVTVPLITLSRDTGGDWKSPVNLA 572

  Fly   585 QFMQQSRKFEGKIP---KLSQTSAA---TGGATAAAEAST 618
            :.:.....:..::|   |.|:.|.|   :.||.|....:|
Human   573 KVVAMDHSYASRVPVPTKFSRISWAPDSSAGAKARQRYAT 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	5..50	CDD:128818	30/40 (75%)
		JmjC	173..289	CDD:396791	81/115 (70%)
KDM4F	NP_001400684.1	JmjN	15..55	CDD:128818	29/39 (74%)
		JmjC	176..292	CDD:396791	81/115 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..474		11/54 (20%)