DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33181 and slc41a2b

DIOPT Version :9

Sequence 1:	NP_001096908.1	Gene:	CG33181 / 318916	FlyBaseID:	FBgn0053181	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_005168582.1	Gene:	slc41a2b / 566242	ZFINID:	ZDB-GENE-100427-2	Length:	555	Species:	Danio rerio

Alignment Length:	568	Identity:	218/568 - (38%)
Similarity:	328/568 - (57%)	Gaps:	70/568 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 TTPPSAYATPPIYQQQLSTLTATTPLDVAPDDKYRLFTIFNGNDPDNEKLSGLPHSTTGSLSSII 193
            |..||.|..  :.:::|:.:...||   .|:...      ||...::.:     ||..||
Zfish    40 TMVPSGYTA--LQEERLAMVDLGTP---KPESHK------NGFHRESRR-----HSDRGS----- 83

  Fly   194 TTSIASSEPDPGAVSGGGGGGGGGGGGGGIGGAGGGGGGGGGNGGIGSGALVAAD----ASSIAG 254
            .|||:.||                                     .|.|.....:    .|.::|
Zfish    84 RTSISLSE-------------------------------------AGDGRYAETEPMLPESRLSG 111

  Fly   255 ING------SSEEKLALNRPGIKQEKWTTILLQVSIPFFLAGIGTIGAGIVLGRVEKWYVFKNVS 313
            ...      |.|||..|....:.:|....:.||:.:||.|||.||:.||:||..|:.|..||.|:
Zfish   112 EEADEEEEESEEEKQQLRNVNMPKESLLAMGLQILVPFLLAGFGTVSAGVVLDIVQHWEAFKTVT 176

  Fly   314 ELFILVPALLGLKGNLDMCLASRLSTQVNLGNMTSRQGVIRMIVGNIALVQVQATVASFLVAMFA 378
            |:||||||||||||||:|.|||||||.||:|.|.|......:|:||:||.||||||..||.|:.|
Zfish   177 EIFILVPALLGLKGNLEMTLASRLSTAVNVGKMDSPIEKWNLIIGNLALKQVQATVIGFLAAVAA 241

  Fly   379 VSVGAAMTGDFYFENMMLLTASAMFTATSSCFVLDFVLVAVILFSQKYRLNPDNLATPLAASIGD 443
            |.:|....|.|...:.:||.:|::.||..:..:...::|.||:.|:|..:||||:|||:|||.||
Zfish   242 VVLGWIPEGKFQISHAVLLCSSSVATAFIASLLQGIIMVGVIVGSKKTGINPDNVATPIAASFGD 306

  Fly   444 VVSISLLSFIASLLYDHIKTHLWITFIVVTCYLVLLPMWVMIVLRNEYTRPVLKSGWVPVLSALC 508
            ::::::|::|:..||:.|.:|.:::|:|...::.|.|:|::|..::..:|.:|.|||.||::|:.
Zfish   307 LITLAILAWISQGLYNCIDSHPYVSFLVCAFFISLTPLWMVISSKHPASRQLLYSGWEPVITAMF 371

  Fly   509 ISGLGGLVLDAAVEVFN--GFVVFQPIINGIGGNLVSVQASKISTMLHQSSIIGIIPPHTQIFEW 571
            ||.:|||:||..|...|  |.||:.|:|||||||||::|:|:|||.||..|..|.:|...:...:
Zfish   372 ISSIGGLILDKTVSDPNLAGMVVYTPVINGIGGNLVAIQSSRISTYLHFHSTPGEVPDEAKGCYY 436

  Fly   572 PWRALFKGVPYAKTARILIAMSIPGNVLFIFAADYINYSTSTVTWVFVLSYLTASLVQVMLLLYI 636
            |.|.........::|::|:.:.|||.::|::..|.:....:::|.||:|.||.|:|.||.|||.|
Zfish   437 PCRTFCGSGANHRSAQVLLLLVIPGQLIFLYTIDLMERGHTSLTVVFILVYLAAALFQVFLLLCI 501

  Fly   637 AHIIVHAMWKWKIDPDNSAIPYLTALGDLLGSSLLAVAWLFTMSVGMQ 684
            |..:||:|||...|||:.:||||||||||||::|||:::.|..::|.|
Zfish   502 ADWMVHSMWKSGKDPDSFSIPYLTALGDLLGTALLALSFHFLWTIGDQ 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33181	NP_001096908.1	MgtE	319..450	CDD:280023	65/130 (50%)
CG33181	NP_001096908.1	MgtE	531..661	CDD:280023	56/129 (43%)
slc41a2b	XP_005168582.1	MgtE	182..313	CDD:280023	65/130 (50%)
slc41a2b	XP_005168582.1	MgtE	396..536	CDD:280023	64/139 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580346
Domainoid	1	1.000	132	1.000	Domainoid score	I5062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9870
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2101
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1059294at2759
OrthoFinder	1	1.000	-	-		FOG0001493
OrthoInspector	1	1.000	-	-		otm24808
orthoMCL	1	0.900	-	-		OOG6_102999
Panther	1	1.100	-	-	O	PTHR16228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900