DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33181 and Slc41a1

DIOPT Version :9

Sequence 1:	NP_001096908.1	Gene:	CG33181 / 318916	FlyBaseID:	FBgn0053181	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001102325.1	Gene:	Slc41a1 / 363985	RGDID:	1311397	Length:	514	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	213/507 - (42%)
Similarity:	308/507 - (60%)	Gaps:	33/507 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SSEPDPGAVSGGGGGG-------GGGGGGGGIGGAGGGGGGGGGNGGIGSGALVAADASSIAGI- 255
            ||:|:|..:....|.|       ..|.|...:.|.....|..|.    |...:|....::..|:
  Rat     2 SSKPEPKDIHQPNGTGPTPSPCSSDGPGREPLAGTSEFLGPDGA----GVEVVVIESRANAKGVR 62

  Fly   256 -------NGS---SEEKLALNR----PGIKQEKWTTILLQVSIPFFLAGIGTIGAGIVLGRVEKW 306
                   |||   ..:.::.:|    |...:|...:|.|||..||.|||.||:.||:||..|:.|
  Rat    63 EEDALLENGSQSNESDDVSTDRVPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVLDIVQHW 127

  Fly   307 YVFKNVSELFILVPALLGLKGNLDMCLASRLSTQVNLGNMTSRQGVIRMIVGNIALVQVQATVAS 371
            .||:.|:|:||||||||||||||:|.|||||||..|:|.|.:.:.:.|||.||:||:||||||..
  Rat   128 EVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGQMDTPKELWRMITGNMALIQVQATVVG 192

  Fly   372 FLVAMFAVSVGAAMTGDFYFENMMLLTASAMFTATSSCFVLDFVLVAVILFSQKYRLNPDNLATP 436
            ||.::.||..|....|.|...:..||.||::.||..:..||..:::.||:.|:|..:||||:|||
  Rat   193 FLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATP 257

  Fly   437 LAASIGDVVSISLLSFIASLLYDHIKTHLWITFIVVTCYLVLLPMWVMIVLRNEYTRPVLKSGWV 501
            :|||:||:::::|||.|:..||..:....:|..:|...::.|||:||::..|:..||.||.|||.
  Rat   258 IAASLGDLITLALLSGISWGLYLELTHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWE 322

  Fly   502 PVLSALCISGLGGLVLDAAVE--VFNGFVVFQPIINGIGGNLVSVQASKISTMLHQSSIIG-IIP 563
            ||:.|:.||.:|||:||..|.  .|.|..||.|:|||:|||||:||||:|||.||.:.:.| ...
  Rat   323 PVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSE 387

  Fly   564 PHTQIFEWPWRALFKGVPYAKTARILIAMSIPGNVLFIFAADYINYSTSTVTWVFVLSYLTASLV 628
            |..:....|....|.....:::||:|..:.:||:::|::....:....:|:|.:|::.|:||:|:
  Rat   388 PTPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAALL 452

  Fly   629 QVMLLLYIAHIIVHAMWKWKIDPDNSAIPYLTALGDLLGSSLLA----VAWL 676
            ||::|||||..:|:.||...:||||.:||||||||||||:.|||    |.||
  Rat   453 QVLILLYIADWMVNWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33181	NP_001096908.1	MgtE	319..450	CDD:280023	66/130 (51%)
CG33181	NP_001096908.1	MgtE	531..661	CDD:280023	53/130 (41%)
Slc41a1	NP_001102325.1	MgtE	140..271	CDD:280023	66/130 (51%)
Slc41a1	NP_001102325.1	MgtE	354..484	CDD:280023	52/129 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340545
Domainoid	1	1.000	131	1.000	Domainoid score	I5017
eggNOG	1	0.900	-	-		E1_COG1824
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1059294at2759
OrthoFinder	1	1.000	-	-		FOG0001493
OrthoInspector	1	1.000	-	-		otm45981
orthoMCL	1	0.900	-	-		OOG6_102999
Panther	1	1.100	-	-	O	PTHR16228
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1062
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800