DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33181 and Slc41a2

DIOPT Version :9

Sequence 1:	NP_001096908.1	Gene:	CG33181 / 318916	FlyBaseID:	FBgn0053181	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_038935350.1	Gene:	Slc41a2 / 362861	RGDID:	1307292	Length:	572	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	222/576 - (38%)
Similarity:	336/576 - (58%)	Gaps:	24/576 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TASTTPPSAYATPPIYQQQLSTLTATTPLDVAPDDKY------RLFTIFNGNDPD-NEKLSGLPH 183
            |.|...|:.|.|....:.....:..|..|:....||:      .:..|:..|..| ::|::|:
  Rat     2 THSKGRPATYKTSASPESGGGFVDWTLNLNTIQSDKFLNLLLSMVPVIYQKNQEDRHKKVNGI-- 64

  Fly   184 STTGSLSSIITTSIASSEP--DPGAVSGGGGGGGGGGGGGGIGGAGGGGGG----GGGNGGIGSG 242
             ....||....|....|||  |....|......|||..............|    .|......:.
  Rat    65 -WQDGLSGAAQTFSKRSEPHLDYHEFSEQAFHSGGGHTPASCSPRYDDYAGYNYCDGREASETTA 128

  Fly   243 ALVAADASSIAGINGSSEEKLALNRPGIKQEKWTTILLQVSIPFFLAGIGTIGAGIVLGRVEKWY 307
            .|...|.||      ..::.:......:.:|....:.||:.:||.|||.||:.||:||..|:.|.
  Rat   129 MLQDEDPSS------QGDDVIVETSQRLPKESSGVMALQILVPFLLAGFGTVSAGMVLDIVQHWE 187

  Fly   308 VFKNVSELFILVPALLGLKGNLDMCLASRLSTQVNLGNMTSRQGVIRMIVGNIALVQVQATVASF 372
            |||||:|:||||||||||||||:|.|||||||.||:|.|.|......:|:||:||.||||||..|
  Rat   188 VFKNVTEVFILVPALLGLKGNLEMTLASRLSTAVNVGKMDSPIEKWNLIIGNLALKQVQATVVGF 252

  Fly   373 LVAMFAVSVGAAMTGDFYFENMMLLTASAMFTATSSCFVLDFVLVAVILFSQKYRLNPDNLATPL 437
            |.|:.|:.:|....|.:|..:.:||.:|::.||..:..:...::|.||:.|:|..:||||:|||:
  Rat   253 LAAVAAIILGWIPEGKYYLSHSILLCSSSVATAFIASLLQGIIMVGVIVGSKKTGINPDNVATPI 317

  Fly   438 AASIGDVVSISLLSFIASLLYDHIKTHLWITFIVVTCYLVLLPMWVMIVLRNEYTRPVLKSGWVP 502
            |||.||::::::|::|:..||..::|:.:|:.:|...:|.|.|:|::|..::..||.||.|||.|
  Rat   318 AASFGDLITLAILAWISQGLYSCLETYYYISPLVCAFFLALTPIWIIIAAKHPATRTVLHSGWEP 382

  Fly   503 VLSALCISGLGGLVLDAAVEVFN--GFVVFQPIINGIGGNLVSVQASKISTMLHQSSIIGIIPPH 565
            |::|:.||.:|||:||..|...|  |.||:.|:|||||||||::|||:|||.||..|:.|.:|..
  Rat   383 VITAMVISSIGGLILDTTVSDPNLVGIVVYTPVINGIGGNLVAIQASRISTYLHLHSLPGELPEE 447

  Fly   566 TQIFEWPWRALFKGVPYAKTARILIAMSIPGNVLFIFAADYINYSTSTVTWVFVLSYLTASLVQV 630
            .:...:|:|..|......|:|::|:...|||:::|::....:....:::|.|||:.||.|:::||
  Rat   448 PKGCSYPFRTFFGSGVNNKSAQVLLLFVIPGHLIFLYTIHLMKSGHTSLTVVFVVVYLLAAVLQV 512

  Fly   631 MLLLYIAHIIVHAMWKWKIDPDNSAIPYLTALGDLLGSSLLAVAWLFTMSVGMQYG 686
            ..||:||..:||..|:...|||:.:||||||||||||::|||:::.|...:|.:.|
  Rat   513 FTLLWIADWMVHRFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLIGDRDG 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33181	NP_001096908.1	MgtE	319..450	CDD:280023	64/130 (49%)
CG33181	NP_001096908.1	MgtE	531..661	CDD:280023	54/129 (42%)
Slc41a2	XP_038935350.1	MgtE	199..331	CDD:396364	64/131 (49%)
Slc41a2	XP_038935350.1	MgtE	413..554	CDD:396364	63/140 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340544
Domainoid	1	1.000	131	1.000	Domainoid score	I5017
eggNOG	1	0.900	-	-		E1_COG1824
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9870
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1059294at2759
OrthoFinder	1	1.000	-	-		FOG0001493
OrthoInspector	1	1.000	-	-		otm45981
orthoMCL	1	0.900	-	-		OOG6_102999
Panther	1	1.100	-	-	O	PTHR16228
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1062
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760