DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33181 and SLC41A1

DIOPT Version :9

Sequence 1:	NP_001096908.1	Gene:	CG33181 / 318916	FlyBaseID:	FBgn0053181	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_776253.3	Gene:	SLC41A1 / 254428	HGNCID:	19429	Length:	513	Species:	Homo sapiens

Alignment Length:	509	Identity:	216/509 - (42%)
Similarity:	307/509 - (60%)	Gaps:	38/509 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SSEPDPGAVSGGGGGG-------GGGGGGGGIGGAGG--GGGGGGGNGGIGSGA----LVAADAS 250
            ||:|:|..|....|.|       ..|.|...:.|...  |..|.|....|.|.|    :...||.
Human     2 SSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGVREEDAL 66

  Fly   251 SIAGINGSSEEKLALNR----PGIKQEKWTTILLQVSIPFFLAGIGTIGAGIVLGRVEKWYVFKN 311
            ...|...:..:.::.:|    |...:|...:|.|||..||.|||.||:.||:||..|:.|.||:.
Human    67 LENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVLDIVQHWEVFQK 131

  Fly   312 VSELFILVPALLGLKGNLDMCLASRLSTQVNLGNMTSRQGVIRMIVGNIALVQVQATVASFLVAM 376
            |:|:||||||||||||||:|.|||||||..|:|:|.:.:.:.|||.||:||:||||||..||.::
Human   132 VTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNMALIQVQATVVGFLASI 196

  Fly   377 FAVSVGAAMTGDFYFENMMLLTASAMFTATSSCFVLDFVLVAVILFSQKYRLNPDNLATPLAASI 441
            .||..|....|.|...:..||.||::.||..:..||..:::.||:.|:|..:||||:|||:|||:
Human   197 AAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATPIAASL 261

  Fly   442 GDVVSISLLSFIASLLYDHIKTHLWITFIVVTCYLVLLPMWVMIVLRNEYTRPVLKSGWVPVLSA 506
            ||:::::|||.|:..||..:....:|..:|...::.|||:||::..|:..||.||.|||.||:.|
Human   262 GDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWEPVIIA 326

  Fly   507 LCISGLGGLVLDAAVE--VFNGFVVFQPIINGIGGNLVSVQASKISTMLHQSSIIG--------I 561
            :.||.:|||:||..|.  .|.|..||.|:|||:|||||:||||:|||.||.:.:.|        .
Human   327 MAISSVGGLILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSEQAPRR 391

  Fly   562 IPPHTQIFEWPWRALFKGVPYAKTARILIAMSIPGNVLFIFAADYINYSTSTVTWVFVLSYLTAS 626
            .|.       |....|.....:::||:|..:.:||:::|::....:....:|:|.:|::.|:||:
Human   392 CPS-------PCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAA 449

  Fly   627 LVQVMLLLYIAHIIVHAMWKWKIDPDNSAIPYLTALGDLLGSSLLA----VAWL 676
            |:||::|||||..:||.||...:||||.:||||||||||||:.|||    |.||
Human   450 LLQVLILLYIADWMVHWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33181	NP_001096908.1	MgtE	319..450	CDD:280023	66/130 (51%)
CG33181	NP_001096908.1	MgtE	531..661	CDD:280023	54/137 (39%)
SLC41A1	NP_776253.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..91		5/30 (17%)
		MgtE	139..270	CDD:396364	66/130 (51%)
		MgtE	353..483	CDD:396364	53/136 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146890
Domainoid	1	1.000	131	1.000	Domainoid score	I5143
eggNOG	1	0.900	-	-		E1_COG1824
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2181
Isobase	1	0.950	-	0	Normalized mean entropy	S4052
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1059294at2759
OrthoFinder	1	1.000	-	-		FOG0001493
OrthoInspector	1	1.000	-	-		otm41844
orthoMCL	1	0.900	-	-		OOG6_102999
Panther	1	1.100	-	-	O	PTHR16228
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3996
SonicParanoid	1	1.000	-	-		X1062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740