Protein Alignment CG33181 and SLC41A1

DIOPT Version :10

• Sequence 1: NP_001096908.1
• Gene: CG33181 / 318916
• FlyBaseID: FBgn0053181
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_776253.3
• Gene: SLC41A1 / 254428
• HGNCID: 19429
• Length: 513
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 216/509 - (42%)
• Similarity: 307/509 - (60%)
• Gaps: 38/509 - (7%)

  Fly   199 SSEPDPGAVSGGGGGG-------GGGGGGGGIGGAGG--GGGGGGGNGGIGSGA----LVAADAS 250
            ||:|:|..|....|.|       ..|.|...:.|...  |..|.|....|.|.|    :...||.
Human     2 SSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGVREEDAL 66

  Fly   251 SIAGINGSSEEKLALNR----PGIKQEKWTTILLQVSIPFFLAGIGTIGAGIVLGRVEKWYVFKN 311
            ...|...:..:.::.:|    |...:|...:|.|||..||.|||.||:.||:||..|:.|.||:.
Human    67 LENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVLDIVQHWEVFQK 131

  Fly   312 VSELFILVPALLGLKGNLDMCLASRLSTQVNLGNMTSRQGVIRMIVGNIALVQVQATVASFLVAM 376
            |:|:||||||||||||||:|.|||||||..|:|:|.:.:.:.|||.||:||:||||||..||.::
Human   132 VTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNMALIQVQATVVGFLASI 196

  Fly   377 FAVSVGAAMTGDFYFENMMLLTASAMFTATSSCFVLDFVLVAVILFSQKYRLNPDNLATPLAASI 441
            .||..|....|.|...:..||.||::.||..:..||..:::.||:.|:|..:||||:|||:|||:
Human   197 AAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATPIAASL 261

  Fly   442 GDVVSISLLSFIASLLYDHIKTHLWITFIVVTCYLVLLPMWVMIVLRNEYTRPVLKSGWVPVLSA 506
            ||:::::|||.|:..||..:....:|..:|...::.|||:||::..|:..||.||.|||.||:.|
Human   262 GDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWEPVIIA 326

  Fly   507 LCISGLGGLVLDAAVE--VFNGFVVFQPIINGIGGNLVSVQASKISTMLHQSSIIG--------I 561
            :.||.:|||:||..|.  .|.|..||.|:|||:|||||:||||:|||.||.:.:.|        .
Human   327 MAISSVGGLILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSEQAPRR 391

  Fly   562 IPPHTQIFEWPWRALFKGVPYAKTARILIAMSIPGNVLFIFAADYINYSTSTVTWVFVLSYLTAS 626
            .|.       |....|.....:::||:|..:.:||:::|::....:....:|:|.:|::.|:||:
Human   392 CPS-------PCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAA 449

  Fly   627 LVQVMLLLYIAHIIVHAMWKWKIDPDNSAIPYLTALGDLLGSSLLA----VAWL 676
            |:||::|||||..:||.||...:||||.:||||||||||||:.|||    |.||
Human   450 LLQVLILLYIADWMVHWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33181	NP_001096908.1	MgtE2	278..457	CDD:441429	94/178 (53%)
		MgtE	531..661	CDD:460317	54/137 (39%)
SLC41A1	NP_776253.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		10/39 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..91		5/30 (17%)
		MgtE	139..273	CDD:460317	69/133 (52%)
		CstA	<219..>358	CDD:441569	60/138 (43%)
		MgtE	353..483	CDD:460317	53/136 (39%)