DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl15 and adgre5b.3

DIOPT Version :10

Sequence 1:NP_723538.3 Gene:mthl15 / 318914 FlyBaseID:FBgn0051720 Length:718 Species:Drosophila melanogaster
Sequence 2:XP_005160275.1 Gene:adgre5b.3 / 792970 ZFINID:ZDB-GENE-121214-275 Length:756 Species:Danio rerio


Alignment Length:851 Identity:155/851 - (18%)
Similarity:270/851 - (31%) Gaps:322/851 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 CAANSLLFKY--RRTVDNAEI-----------------YQCASAA----SNISELPDLAQVI-GK 65
            |:..:|.:|:  |:.||..|.                 |.|..||    |......|:.:.: .:
Zfish    16 CSGCALGYKFVKRKCVDEDECETPGMCGDAQCVNTDGSYYCTCAAGFKMSQTGPCKDINECLEDE 80

  Fly    66 LIPPMGLGLEKAIND------SGHSQFALSKCQNFSSLSISDLGERTLNLRNNSCIGLLNRRLIV 124
            ||.|..:..|.....      :||.....::|::......|..|      .:.||.         
Zfish    81 LICPAQMRCENTFGSYVCVCPTGHQWKNEAECEDEDECLSSPCG------LHRSCF--------- 130

  Fly   125 LSCEFEKNVPSQSVGFVNKCCPQGFIYV-----SENNTCKPGESDFFVYTSIISSPIIFFDNTLN 184
                   |.|.   .||.||.| ||..:     ::.|.|.............|::|     ...:
Zfish   131 -------NTPG---SFVCKCSP-GFRELEGGMCADINECSESPDVCGTNGDCINNP-----GGFS 179

  Fly   185 CSDHRALVEYTLSSGKVHFHNNSLIWKDGTNSLPSSKFCIEAIHDSDDADLDRGALPEQ-----K 244
            |..|:....|                  |.|   .|| |||...|....:.|.|..||:     .
Zfish   180 CRCHQGFTNY------------------GNN---QSK-CIEMSCDQFKPEPDAGNTPEKLKHLMS 222

  Fly   245 FLVRACQEM-----------KICQKIPCIRRCCAEGEMYAKGNFSTYCKIDGTDFKFEGFQNLNI 298
            .|:.:|:.:           |:.:.:     |.:..::.::||.:     ||        :.|::
Zfish   223 LLMNSCKSLNDPHGEHFTAEKLLENL-----CNSTDDLLSEGNVA-----DG--------ETLSV 269

  Fly   299 NANFSKPSDFGIVHGLQCPKFRLDPDNF------------PDDSHTINPSNGSLIIHNTFKTYTN 351
            ..:..:.|...|...|:.|..:::..|.            |..|.|:  |.||...:.:::|...
Zfish   270 FLDAVENSMRLIGPQLKDPVTKMETQNTYAEVAVTRNQTPPSGSVTL--STGSAHFNTSWETVVG 332

  Fly   352 TQY------------------------CVERVRPNQKLYTFLCFDNKVVT--------------- 377
            ..|                        ..|:....:|..|:. .::||||               
Zfish   333 KSYPGFAFVALVSYKDMNSSSDLFNSMAREKSDVKEKQITYK-LNSKVVTAVVSNPDTKHLSKPV 396

  Fly   378 -------------------------GDR----------------------------IRFKMYP-- 387
                                     .:|                            :...:||  
Zfish   397 TLIFTHEEKRAESEGVAYSCVYWSESERGWSGRGCELAWSNSTHTACSCSHLSSFAVLMALYPVE 461

  Fly   388 ----------IGLLISCCFYALTLIVYISIAKLRNLPGKILICLVSSLFAAYLGIALGQLRPTSN 442
                      :||::|.....|.::.:.....::.....|.:.|...||.|.|....| :..|.|
Zfish   462 DTFELVVITRVGLVLSLICLILCILTFRFCRSIQGTRNSIHLHLSVCLFIADLVFLCG-ISSTHN 525

  Fly   443 DDICFLSGFFVYFCLMAAFSWMNITSFDIWK----TFGSTKLKSCEKSDLRRQFIWYSCYGWGLP 503
            ...|.:....::|..::||.||.:....:::    .|.:|         |:..:::  ..|:|:|
Zfish   526 QVACAIVAGLLHFFFLSAFCWMLLEGVQLYRMVVLVFHTT---------LKHLYMY--AVGYGVP 579

  Fly   504 TLLTGITIAFTKSDILPDAVRPNFGHGR-CWFTYDSFGSASLLFFSGPVGILFIINLVLFVLTMK 567
            .::..|:..         ||...:|..| ||.:.:.:   .:|.|..||.|:.|:|:.:|::|  
Zfish   580 LVIVSISAI---------AVPKGYGTDRHCWLSLEGY---LILSFFIPVCIIVILNITVFIIT-- 630

  Fly   568 YCNKVKNEIYKMQSLNSDKPVLKRRFFQDKTRFVMNT---KLCFVMGITWLL----------EIV 619
                |.....|..|||.|...|      .|.|..:.|   :|| |:|.:|:.          |::
Zfish   631 ----VWKLALKFSSLNPDLSKL------HKIRSFLATAVAQLC-VLGGSWVFGFFLFQKNGTEVM 684

  Fly   620 SILFYDHKKTFFWTISDSFNVLLGIFVFIIF-------------VFKRRIYNEIMFKFGLQS-NP 670
            ..||.            ..|.|.|..:||:.             :|.|...|:....:.:.| .|
Zfish   685 LYLFI------------ILNSLQGALIFIMHCLLSKQVRVEYRSLFMRMCSNKKKGDYSVSSTEP 737

  Fly   671 STASTR 676
            |.:|.:
Zfish   738 SHSSQK 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl15NP_723538.3 Mth_Ecto <247..355 CDD:448329 21/154 (14%)
7tmB3_Methuselah-like 379..665 CDD:410632 70/356 (20%)
TM helix 1 381..406 CDD:410632 6/36 (17%)
TM helix 2 415..437 CDD:410632 7/21 (33%)
TM helix 3 447..474 CDD:410632 5/30 (17%)
TM helix 4 492..512 CDD:410632 4/19 (21%)
TM helix 5 537..569 CDD:410632 9/31 (29%)
TM helix 6 595..622 CDD:410632 9/39 (23%)
TM helix 7 627..654 CDD:410632 6/39 (15%)
adgre5b.3XP_005160275.1 EGF_CA 32..>62 CDD:214542 6/29 (21%)
EGF_CA 72..103 CDD:429571 5/30 (17%)
EGF_CA <121..152 CDD:214542 13/56 (23%)
EGF_CA 154..188 CDD:214542 6/38 (16%)
GPS 416..460 CDD:197639 2/43 (5%)
7tm_GPCRs 463..723 CDD:475119 66/308 (21%)
TM helix 1 466..490 CDD:410628 4/23 (17%)
TM helix 2 499..520 CDD:410628 7/21 (33%)
TM helix 3 530..552 CDD:410628 5/21 (24%)
TM helix 4 570..586 CDD:410628 3/17 (18%)
TM helix 5 605..628 CDD:410628 7/25 (28%)
TM helix 6 655..677 CDD:410628 6/22 (27%)
TM helix 7 682..707 CDD:410628 8/36 (22%)

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