DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl15 and mthl7

DIOPT Version :9

Sequence 1:	NP_723538.3	Gene:	mthl15 / 318914	FlyBaseID:	FBgn0051720	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	125/528 - (23%)
Similarity:	203/528 - (38%)	Gaps:	126/528 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LIWKDGTNS-LPSSKF-------CIEAIHDS---DDADL--------------DRGALPEQKFLV 247
            ||:.:.:|: :|...:       .||..:||   ||.::              |....|.:|.|
  Fly    14 LIFTNNSNADIPGCNYYDTVDISYIERQNDSYLYDDIEIPASLTGYYEFRQFGDGSITPIEKHL- 77

  Fly   248 RACQEMKICQKIPCIRRCCAEGEMYAKGNFSTYCKIDGTDFK-FEGFQNLNINANFSKP------ 305
            |||    :|...||||.||......|.|......|.:...|| :..|..:::.|.....
  Fly    78 RAC----VCSVRPCIRICCPAKNFLANGKCDDGLKEELARFKPYIYFTYMDLQARVPLTDMAIIR 138

  Fly   306 ------------SDF---------------GIVHGLQCPKFRLDPDNFPDDSHTINPSNGSLIIH 343
                        |||               |::...|..||.:..|.|      :...:..|..|
  Fly   139 DEFFDCDEMIYISDFNYFLEEVSIQIFNKCGLIVWFQDGKFWVTVDLF------MEKQDYCLYRH 197

  Fly   344 NTFKTYTNTQY-----CVERVRPNQ---KLYTFLCFDNKVVTGDRIRFKMYPIGLLISCCFYALT 400
            |....:..:.:     |...:.|..   .:.|.:||                          .||
  Fly   198 NFDSDFPKSMWIIRHRCTSHISPGSLEILIITMICF--------------------------VLT 236

  Fly   401 LIVYISIAKLRNLPGKILICLVSSLFAAYLGIALGQLRPTSNDDICFLSGFFVYFCLMAAFSWMN 465
            :.||:.|.||||:.||.::|.:.|.|...|.:.|..|...:.  ||..:|:..:|..||:..|::
  Fly   237 IAVYLYIKKLRNVTGKCIVCCIVSRFIQCLIMILDHLNLLNG--ICSPAGYSSHFFRMASNLWLS 299

  Fly   466 ITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGWGLPTLLTG---ITIAFTKSDILPDAVRPNF 527
            :.|:..||.     |.|..:.|...:|:.|:.:.|....::||   |.....::|.......|..
  Fly   300 VISYHTWKV-----LTSLNRVDPNYRFLRYNAFVWSTAAIMTGSIYIVNQIWENDPSKWNWLPLV 359

  Fly   528 GHGRCWFTYDSFGSASLLFFSGPVGILFIINLVLFVLTMKYCNKVKNEIYKMQSLNSDKPVLKRR 592
            |..||  :...:..:..::.|||...|...|:.:|.||..|..|||..|.|.  .|.::..:...
  Fly   360 GFIRC--SVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKF--TNEEEGRINCI 420

  Fly   593 FFQDKTRFVMNTKLCFVMGITWLLEIVSILFYDHKKTFFW----TISDSFNVLLGIFVFIIFVFK 653
            .|..:| ::...:|..|||:||:..::.   |..:...||    .||:.|:...||.:|::.|.|
  Fly   421 NFDSQT-YLQFLRLSIVMGLTWIFNVIP---YSARLHIFWEWVGIISEYFHSAFGIVLFVLLVLK 481

  Fly   654 RRIYNEIM 661
            |..:..:|
  Fly   482 RSTWTLMM 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:299804	29/146 (20%)
mthl15	NP_723538.3	7tm_4	385..646	CDD:304433	72/267 (27%)
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	39/197 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070