DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl15 and mth

DIOPT Version :9

Sequence 1:	NP_723538.3	Gene:	mthl15 / 318914	FlyBaseID:	FBgn0051720	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_728521.1	Gene:	mth / 38058	FlyBaseID:	FBgn0023000	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	146/515 - (28%)
Similarity:	224/515 - (43%)	Gaps:	105/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 DLDRGALPE---QKFL--VRACQEMKICQKIPCIRRCCAEGEMYAKG----NFS----------T 279
            :.|...||:   ||..  :|.|    :|:..||:|.||....:...|    |.|          .
  Fly    62 EYDFRILPDDSKQKVARHIRGC----VCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFL 122

  Fly   280 YCKIDGTDFKFEGFQN-LNINANFSKPSDFGIVHGLQCPKFRLDPDNFPDDSHTINPSNGSLIIH 343
            ...:|........|:| |.:..:...|.|     |:    |.|| :....|.:|:. .||:...|
  Fly   123 NVTLDDGSVSRRHFKNELIVQWDLPMPCD-----GM----FYLD-NREEQDKYTLF-ENGTFFRH 176

  Fly   344 NTFKTYTNTQYCVE------------RVRPNQKLYTFLCFDNKVVTGDRIRFKMYPIGLLISCCF 396
            ....|....:||::            |:.|:.      |.....:||.       .:.::.|...
  Fly   177 FDRVTLRKREYCLQHLTFADGNATSIRIAPHN------CLIVPSITGQ-------TVVMISSLIC 228

  Fly   397 YALTLIVYISIAKLRNLPGKILICLVSSLFAAYLGIALGQLRPTSNDDICFLSGFFVYFCLMAAF 461
            ..||:.||:.:.||:||.||..||.:..||..||.:.|...:.:.:  .|..:||..||.:||||
  Fly   229 MVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISIS--FCKPAGFLGYFFVMAAF 291

  Fly   462 SWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGWGLPTLLTGITIAFTKSDILPDAV--- 523
            .|:::.|..:|.||..:..|: .:.....:|:.|:.|.||:..:|||||       :|.|.:
  Fly   292 FWLSVISLHLWNTFRGSSHKA-NRFLFEHRFLAYNTYAWGMAVVLTGIT-------VLADNIVEN 348

  Fly   524 ---RPNFGH-GRCWFTYDSFGSASLLFFSGPVGILFIINLVLFVLTMKYCNKVKNEIY------- 577
               .|..|| |.||. |....|| :|:|.||:..|...|:.:|:||.|....||.:|.
  Fly   349 QDWNPRVGHEGHCWI-YTQAWSA-MLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQE 411

  Fly   578 KMQSLNSDKPVLKRRFFQDKTRFVMNTKLCFVMGITWLLEIVSILFYDHKKTF--FWTISDSFNV 640
            :.|.|||||        |..|.|:   :|..:||::|.|||.| .|....:|:  .:.::|..|.
  Fly   412 RKQKLNSDK--------QTYTFFL---RLFIIMGLSWSLEIGS-YFSQSNQTWANVFLVADYLNW 464

  Fly   641 LLGIFVFIIFVFKRRIYNEIMFKFGLQSNPSTASTRTRAG-VTKSYAPTSTAMTTLRHSP 699
            ..||.:||:||.||..:..:..:...:|..|..|.|:.|. :|....|.:.|    |:||
  Fly   465 SQGIIIFILFVLKRSTWRLLQERNHPKSTRSVISNRSMASRITVGTTPKNKA----RNSP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:299804	27/122 (22%)
mthl15	NP_723538.3	7tm_4	385..646	CDD:304433	90/276 (33%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:284145	36/167 (22%)
mth	NP_728521.1	7tm_4	219..416	CDD:304433	68/208 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070