DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl15 and mthl10

DIOPT Version :10

Sequence 1:NP_723538.3 Gene:mthl15 / 318914 FlyBaseID:FBgn0051720 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_788446.2 Gene:mthl10 / 38057 FlyBaseID:FBgn0035132 Length:585 Species:Drosophila melanogaster


Alignment Length:568 Identity:148/568 - (26%)
Similarity:239/568 - (42%) Gaps:101/568 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 PIIFFDNTLNCSDHRALVEYTLSSGKVHFHNNSLIWKDGTNSLPSSKFCIEAIHDSDDADLDRGA 239
            |..|:| |:|.:.||.            |.|.|..:. ||..........:.||.|....:    
  Fly    55 PCNFYD-TVNLTGHRL------------FPNGSYDYY-GTIVPAELVGTYDYIHSSLTERI---- 101

  Fly   240 LPEQKFLVRACQEMKICQKIPCIRRCCAEGEMY---AKGNFSTYCKIDGTD-----------FKF 290
              |.:..||.|    :|:...|:..||...:::   ..|     |.||.:|           ..|
  Fly   102 --EVREHVRGC----VCKFKSCLNICCPWRQVFNSEVDG-----CIIDHSDNRTWPDPPMLNITF 155

  Fly   291 EGFQNLNINANFSKPSDFGIVHGLQCPK-FRLDPDNFPDDSHTINPSNGS--------LIIHNTF 346
            .....:.:|. |::   |.|.....||| |.|.|:....|.:.:. .|||        ||..|.|
  Fly   156 RNESTILVNM-FTQ---FAIQSFRPCPKMFSLQPETNNWDDYLLF-ENGSMLRVDDKLLIRKNEF 215

  Fly   347 ---KTYTNTQYCVERVRPNQKLYTFLCFDNKVVTGDRIRFKMY-PIGLLISCCFYALTLIVYISI 407
               .||.|.......:.|          .|..:..|....|:. ...::.|..|..||:.||:.|
  Fly   216 CMVPTYVNESDMFYTIHP----------ANCDMQDDHSTVKIINSYAMMFSIPFMMLTIAVYLLI 270

  Fly   408 AKLRNLPGKILICLVSSLFAAYLGIALGQLRPTSNDDI-CFLSGFFVYFCLMAAFSWMNITSFDI 471
            .:|||..||.|:|.:..|...|..:...||.......: |.:.|:..||..|.|:.|:::.|||:
  Fly   271 PELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATGVTCKVFGYTAYFFFMGAYMWLSVISFDL 335

  Fly   472 WKTFGSTKLKSCEKSDLRRQFIWYSCYGWGLPTLLTGITIAFTKSDILPDAVRPNFGHG-RCWFT 535
            |..|..|  :...:...:::|::||.|.||:..:....|....:...||..::|..|.| .||. 
  Fly   336 WHNFRGT--RGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWL- 397

  Fly   536 YDSFGSASLLFFSGPVGILFIINLVLFVLTMKYCNKVKNEIYK-MQSLNSDKPV---LKRRFFQ- 595
             |....|::::|.||:..:.:.|.::|::|....:.|:.|:.: :.|.||.|.:   ..:||:: 
  Fly   398 -DMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRA 461

  Fly   596 -DKTRFVMNTKLCFVMGITWLLEIVSILFYDHK---KTFFWTISDSFNVLLGIFVFIIFVFKRRI 656
             ...||.:..:|..:||||||.|::|......|   |.|:  |||..|.:.|..:|::||.|:::
  Fly   462 WSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFY--ISDLANAMQGFLIFMLFVMKKKV 524

  Fly   657 YNEI-----MFKFGLQSNPSTASTRTRAGVTKSYAPTSTAMTTLRHSP 699
            .:.|     ..:.|.....|..||:|.:        :|.|..:|...|
  Fly   525 KHLITNRCSSVRDGSNQRQSQYSTKTTS--------SSVANLSLHEKP 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl15NP_723538.3 Mth_Ecto <247..355 CDD:448329 34/133 (26%)
7tmB3_Methuselah-like 379..665 CDD:410632 87/302 (29%)
TM helix 1 381..406 CDD:410632 7/25 (28%)
TM helix 2 415..437 CDD:410632 6/21 (29%)
TM helix 3 447..474 CDD:410632 10/26 (38%)
TM helix 4 492..512 CDD:410632 7/19 (37%)
TM helix 5 537..569 CDD:410632 8/31 (26%)
TM helix 6 595..622 CDD:410632 11/28 (39%)
TM helix 7 627..654 CDD:410632 11/29 (38%)
mthl10NP_788446.2 Methuselah_N 56..236 CDD:429053 50/223 (22%)
7tmB3_Methuselah-like 242..533 CDD:410632 86/296 (29%)
TM helix 1 244..269 CDD:410632 7/24 (29%)
TM helix 2 278..300 CDD:410632 6/21 (29%)
TM helix 3 311..338 CDD:410632 10/26 (38%)
TM helix 4 354..374 CDD:410632 7/19 (37%)
TM helix 5 401..430 CDD:410632 7/28 (25%)
TM helix 6 446..489 CDD:410632 15/42 (36%)
TM helix 7 497..522 CDD:410632 10/26 (38%)

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