Protein Alignment mthl15 and mthl4

DIOPT Version :10

• Sequence 1: NP_723538.3
• Gene: mthl15 / 318914
• FlyBaseID: FBgn0051720
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 150/594 - (25%)
• Similarity: 248/594 - (41%)
• Gaps: 149/594 - (25%)

  Fly   149 FIYVSENNTCKPGESDFFVYTSIISSPIIFFDNTLNCSDHRALVEYTLSSGKVHFHNNSLIWKDG 213
            |:.:.::|...|| .|||....|..:|                          .|.|.|.:: :|
  Fly    10 FLLMPKSNAEIPG-CDFFDTVDISKAP--------------------------RFSNGSYLY-EG 46

  Fly   214 TNSLPSSKFCIEAIHD----SDDADLDRGALPEQKFL--VRACQEMKICQKIPCIRRCC------ 266
            . .:|:.   :.|.:|    :||:        ::|..  ||.|    .|...||||.||
  Fly    47 L-LIPAH---LTAEYDYKLLADDS--------KEKVASHVRGC----ACHLRPCIRFCCPQYQKM 95

  Fly   267 ---------AEGEMYAKGNFSTYCKIDGTDFKFEGFQNLNINANFSKPSDFGIVHGLQCPKFRLD 322
                     :|.|:.....|......||:..:....::|.:.::.:||.         ||:....
  Fly    96 QKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPG---------CPRMYFL 151

  Fly   323 PDNFPDDSHTINPSNGSLIIHNTFKTYTNTQYCVERVRPNQKLYTFLCFDNKVVTGDRIRFKMY- 386
            ....|.:..|:. .||||:.|......:..:|||:.          |.|.:     |.||...:
  Fly   152 NHELPGNEFTLF-ENGSLLRHWDKVELSKREYCVQH----------LSFKD-----DSIRIAPHF 200

  Fly   387 ------------PIGLLISCCFYALTLIVYISIAKLRNLPGKILICLVSSLFAAYLGIALGQLRP 439
                        .:.::||.....||:.||:.:.|||||.||..||.::|||..|..:.|...:.
  Fly   201 CPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKY 265

  Fly   440 TSNDDICFLSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRR-----QFIWYSCYG 499
            :|.  .|..:||..||.:||||.|:::....:...|      |...:.|.|     .|..|:.|.
  Fly   266 SSG--FCVTAGFLGYFSVMAAFFWLSVIGIHLRIKF------SLASNCLHRLLPENPFRAYNLYA 322

  Fly   500 WGLPTLLTGITIAFTKSDILP-DAVRPNFGHGR-CW-FTYDSFGSASLLFFSGPVGILFIINLVL 561
            ||:|.::|.||  :|...::. :.:||..|.|: || :|.|   ...:::|.||:.:|...|:::
  Fly   323 WGIPLIMTAIT--YTADQVVKNEKLRPRVGVGKNCWIYTGD---MTVMIYFYGPMLLLIAFNIIM 382

  Fly   562 FVLTMKYC----NKVKNEIYKMQSLNSDKPVLKRRFFQDKTRFVMNTKLCFVMGITWLLEIVSIL 622
            |||:..|.    ..||..::|.|:         .:...|:..|.:..:|..:||::|..||:|.|
  Fly   383 FVLSAIYIYNIKKNVKGLVHKQQT---------NQQINDQQMFAIFLRLFILMGLSWSFEILSFL 438

  Fly   623 FYDHKKTFFWT----ISDSFNVLLGIFVFIIFVFKRRIYNEIMFKFGLQSNP-STASTRTRAGVT 682
            .   .|...|.    ::|.||...|..:|::|:.|..|. :::...|.|:.| |..::|::|.
  Fly   439 L---TKQQAWARALMVADYFNWSQGTIIFVLFILKPSIL-KLIIAGGRQNLPGSHHNSRSKAA-- 497

  Fly   683 KSYAPTSTA 691
             .|..|.||
  Fly   498 -RYNSTHTA 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:448329	27/122 (22%)
		7tmB3_Methuselah-like	379..665	CDD:410632	89/314 (28%)
		TM helix 1	381..406	CDD:410632	8/37 (22%)
		TM helix 2	415..437	CDD:410632	9/21 (43%)
		TM helix 3	447..474	CDD:410632	9/26 (35%)
		TM helix 4	492..512	CDD:410632	9/19 (47%)
		TM helix 5	537..569	CDD:410632	9/31 (29%)
		TM helix 6	595..622	CDD:410632	9/26 (35%)
		TM helix 7	627..654	CDD:410632	8/30 (27%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	50/245 (20%)
		7tmB3_Methuselah-like	205..477	CDD:410632	86/297 (29%)
		TM helix 1	207..232	CDD:410632	6/24 (25%)
		TM helix 2	241..263	CDD:410632	9/21 (43%)
		TM helix 3	271..298	CDD:410632	9/26 (35%)
		TM helix 4	315..335	CDD:410632	9/21 (43%)
		TM helix 5	361..390	CDD:410632	9/31 (29%)
		TM helix 6	411..438	CDD:410632	9/26 (35%)
		TM helix 7	446..471	CDD:410632	6/24 (25%)