Protein Alignment mthl15 and mthl1

DIOPT Version :10

• Sequence 1: NP_723538.3
• Gene: mthl15 / 318914
• FlyBaseID: FBgn0051720
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 707
• Identity: 168/707 - (23%)
• Similarity: 277/707 - (39%)
• Gaps: 182/707 - (25%)

  Fly   117 LLNRRLIVLSCEFEKNVPSQSVG---------FVNKCCPQGFIYVSENNTCKPGESDFFVYTSII 172
            :|.:.|:.:|...|:..|..:..         .:||||..| .|::: .||..|....::....:
  Fly    26 ILLQTLVSMSLAIEEMSPPPAAPPRPSPPPTVKLNKCCHSG-EYLND-GTCIAGSEALWLPMVYL 88

  Fly   173 -----------SSP--IIFFDNTL-NC-SDHRALVEYTLSSGKVHFHNNSLIWKDGTNSLPSSKF 222
                       :||  :.|..||. .| .|....:..:..:..:.|.|.:|..::....:..|.:
  Fly    89 VQQQRFFEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDY 153

  Fly   223 CIE------AIHDS------DDADLDRGALPEQ---KFLVRACQEMKICQKIPCIRRCCAEGEMY 272
            |::      .::||      :|.|.....|.:|   |..:|             :.:||.:.
  Fly   154 CVDWEVAVVCLNDSQPINALEDPDYAANPLVQQEPPKASLR-------------LSKCCGKW--- 202

  Fly   273 AKGNFSTYCKIDGTDFKFEGFQNLNINANFSKPSDFGIVHGLQCPKFRLDPDNFPDDSHTIN--- 334
              |:::|.            .||.::     :|:....|.||    .||.| ..|:.|:..:
  Fly   203 --GSYNTQ------------LQNCDL-----QPNHQAAVDGL----LRLSP-QLPEGSYQTSYGL 243

  Fly   335 -----PSNGSL--------IIHNT------FKTYTNTQYCVERVRPNQKLYTFLC---------- 370
                 |...|:        :..||      .|..:..|||:|..:...::....|
  Fly   244 PDCGQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGA 308

  Fly   371 --FDNKV------VTGDRIRFKMYPIGLLISCCFYALTLIV-YISIAKLRNLPGKILICLVSSLF 426
              .|..:      ..|..::..:...|:|:|..|.:.||:. ::..|....|..:..||.|:.|.
  Fly   309 GIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLL 373

  Fly   427 AAYLGIAL----GQLRPTSNDDICFLSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSD 487
            ...:.:|:    ..|:|.|  ..|......:.|..:|||.|:|...|:||.||...:..|.|::.
  Fly   374 FGKILLAIEELSSSLQPGS--AACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQ 436

  Fly   488 --LRRQFIWYSCYGWGLPTLLTGITIAFTKSDILPDA--VRPNFGHGRCWFTYDSFGSASLLFFS 548
              |||..  ||.|.||.|.|:|.:....   |.||:.  :||.||...|||  |:...:...:|.
  Fly   437 EALRRYL--YSLYAWGGPLLITFVAACV---DQLPETTLLRPGFGQLYCWF--DNRNLSIFAYFY 494

  Fly   549 GPVGILFIINLVLFVLTMKY--CNKVKNEIYKMQSLNSDKPVLKRRFFQDKTRFVMNTKLCFVMG 611
            ||:|:|...|:.|||.|...  |...|.:..|.   :|:|..|.|          :..||..|||
  Fly   495 GPIGLLLCANIALFVSTTHQLTCGLWKRDDVKS---SSEKSALGR----------VCLKLVVVMG 546

  Fly   612 ITWLLEIVSILFYDHKKTFFWTISDSFNVLLGIFVFIIF------------VFKRRIYNEIM-FK 663
            :||:.:|:|.|.......:|:|  |..|.|.|:|:||:.            :|..|:.::|. ..
  Fly   547 VTWIADILSWLVGGPHGVWFFT--DLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTT 609

  Fly   664 FGLQSNPSTASTRTRAGVTK----SYAPTSTAMTTLRHSPGSCEFKRQTSTRPENEV 716
            .|:|.:.|:....:.||.|:    :...|:|..||..|.|         |...|:||
  Fly   610 NGVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMP---------SNPAEDEV 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:448329	22/129 (17%)
		7tmB3_Methuselah-like	379..665	CDD:410632	91/309 (29%)
		TM helix 1	381..406	CDD:410632	6/25 (24%)
		TM helix 2	415..437	CDD:410632	5/25 (20%)
		TM helix 3	447..474	CDD:410632	9/26 (35%)
		TM helix 4	492..512	CDD:410632	8/19 (42%)
		TM helix 5	537..569	CDD:410632	11/33 (33%)
		TM helix 6	595..622	CDD:410632	9/26 (35%)
		TM helix 7	627..654	CDD:410632	10/38 (26%)
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	88/295 (30%)
		TM helix 1	327..352	CDD:410632	6/24 (25%)
		TM helix 2	362..384	CDD:410632	5/21 (24%)
		TM helix 3	396..423	CDD:410632	9/26 (35%)
		TM helix 4	441..461	CDD:410632	9/21 (43%)
		TM helix 5	485..515	CDD:410632	10/29 (34%)
		TM helix 6	530..557	CDD:410632	12/36 (33%)
		TM helix 7	562..587	CDD:410632	9/26 (35%)