DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl15 and mthl12

DIOPT Version :10

Sequence 1:NP_723538.3 Gene:mthl15 / 318914 FlyBaseID:FBgn0051720 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster


Alignment Length:583 Identity:135/583 - (23%)
Similarity:235/583 - (40%) Gaps:166/583 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 KC-CPQGFIYVSENNTCKPGESDFFVYTSIISSPIIFFDNTLNCSDHRALVEYTLSSGKVHFHNN 206
            || |....:.:::|::.|              .|...:|.|:|.|..:.|             |:
  Fly     6 KCFCTLIIVTIAKNSSAK--------------IPHCKYDETINISHFKRL-------------ND 43

  Fly   207 SLIWKDGTNSLPSS---KFCIEAIHDSDDADLDRGALPEQKFLVRACQEMKICQKIPCIRRCCAE 268
            :.|::.  ..:|::   :|..:.:       :|...:|.:...:|.|    ||:..||||.|||.
  Fly    44 AYIYEH--FEIPANLTGEFDYKEL-------MDGSKVPTEFPNLRGC----ICKVRPCIRICCAR 95

  Fly   269 GEMYAKGNFS----TYCKIDGTDFKFEG-------FQNLNINANFS-----------KPSDFGIV 311
            ..:.:.|..|    ...|:...|...:.       ...||:...::           :|.| .||
  Fly    96 KNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCD-EIV 159

  Fly   312 HGLQCPKFRLDPDNFPDDSHTINPSNGSLIIHNTFKTYTNTQYCV---------ERVRPNQKLYT 367
                         :...|.:|| ..:||:::|.:.:..:|.|||:         |.:|    :..
  Fly   160 -------------SLKRDEYTI-LKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIR----IIN 206

  Fly   368 FLCFDNKVVTGDRIRFKMYPIGLL--ISCCFYALTLIVYISIAKLRNLPGKILICLVSSLFAAYL 430
            ..|:.| |:.|         |..|  ||...:.|||.||:|:.|||||.||.|||.:.|:|..|.
  Fly   207 RRCYRN-VMPG---------IAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYF 261

  Fly   431 GIALGQLRPTSNDDICFLSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWY 495
            ...:...|...:  ||..:|:..||..|:::.|.::.||.:|:.|     .|..:.:.:.:|:.|
  Fly   262 IWTMDYFRLLQS--ICSAAGYMKYFFSMSSYLWFSVVSFHLWELF-----TSLNRHEPQYRFLIY 319

  Fly   496 SCYGW---GLPTLLTGITIAFT----------KSDILPDAVRPNFGHGRCWFTYDSFGSASLLFF 547
            :.:.|   .:||:     :.|:          ||:.|     |..|:..|  :...:.|:|..:.
  Fly   320 NTFVWCTAAIPTV-----VIFSMNQMWENDPGKSEWL-----PLVGYFGC--SVKDWNSSSWFYS 372

  Fly   548 SGPVGILFIINLVLFVLTMKYCNKVKNEIYKMQSLNSDKPVLKRRFFQDKTR-----------FV 601
            ..|:.||...|:::||||..|..|||..:              :.|.|...|           ::
  Fly   373 HIPIVILNSFNVIMFVLTAIYIWKVKKGV--------------KSFAQHDERNTTCLEFNVQTYI 423

  Fly   602 MNTKLCFVMGITWLLEIVSILFYDHK---KTFFWTISDSFNVLLGIFVFIIFVFKRRIYNEIM 661
            ...:|..:||.:|||:.::.|..|..   .|....::...|...||.:|::.:.|...:..||
  Fly   424 QFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl15NP_723538.3 Mth_Ecto <247..355 CDD:448329 29/129 (22%)
7tmB3_Methuselah-like 379..665 CDD:410632 81/312 (26%)
TM helix 1 381..406 CDD:410632 9/26 (35%)
TM helix 2 415..437 CDD:410632 8/21 (38%)
TM helix 3 447..474 CDD:410632 8/26 (31%)
TM helix 4 492..512 CDD:410632 5/22 (23%)
TM helix 5 537..569 CDD:410632 10/31 (32%)
TM helix 6 595..622 CDD:410632 8/37 (22%)
TM helix 7 627..654 CDD:410632 5/29 (17%)
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 44/226 (19%)
7tmB3_Methuselah-like 220..488 CDD:410632 80/300 (27%)
TM helix 2 246..268 CDD:410632 8/21 (38%)
TM helix 3 276..303 CDD:410632 8/26 (31%)
TM helix 4 316..336 CDD:410632 5/24 (21%)
TM helix 5 364..394 CDD:410632 10/29 (34%)
TM helix 6 410..444 CDD:410632 7/33 (21%)
TM helix 7 449..479 CDD:410632 5/29 (17%)

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