DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl15 and Adgrb2

DIOPT Version :9

Sequence 1:NP_723538.3 Gene:mthl15 / 318914 FlyBaseID:FBgn0051720 Length:718 Species:Drosophila melanogaster
Sequence 2:XP_011238809.1 Gene:Adgrb2 / 230775 MGIID:2451244 Length:1582 Species:Mus musculus


Alignment Length:374 Identity:73/374 - (19%)
Similarity:152/374 - (40%) Gaps:115/374 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   388 IGLLISCCFYALTLIVYISIAKLRNLPGKILI---CLVSSLFAAYLGIALGQLRPTSNDDICFLS 449
            ||..:||......|.:|.:..:.......|::   ||  |:.|:.:.|.:||.|..|. .:|.::
Mouse   932 IGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCL--SILASNILILVGQSRVLSK-GVCTMT 993

  Fly   450 GFFVYFCLMAAFSWMNITSFDIWKTFGS------TKLKSCEKSDLRRQFIWYSCYGWGLPTLLTG 508
            ..|::|..:::|.|: :|  :.|:::.:      |:|       :|::|:   |.|||||.|:..
Mouse   994 AAFLHFFFLSSFCWV-LT--EAWQSYLAVIGRMRTRL-------VRKRFL---CLGWGLPALVVA 1045

  Fly   509 ITIAFTKSDILPDAVRPNFGHGR---CWFTYDSFGSASLLF-FSGPVGILFIINLVLFVLTMKYC 569
            :::.||::.          |:|.   ||.:.:    ..||: |.||..::.::|:::.::..   
Mouse  1046 VSVGFTRTK----------GYGTSSYCWLSLE----GGLLYAFVGPAAVIVLVNMLIGIIVF--- 1093

  Fly   570 NKVK-----NEIYKMQSLNSDK------------------PVLKRRFFQDKTRFVMN-----TKL 606
            ||:.     ::..|.|...|::                  |:|.....::..|...|     ::|
Mouse  1094 NKLMARDGVSDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAIRLSWNLWGYGSQL 1158

  Fly   607 CF-----------------VMGITWLLEIVSILFYDHKKTFFWTISDSFNVLLGIFVFIIFVFKR 654
            |.                 ::.:||:..::::.  |.:...|..:...||...|..:..:..|.|
Mouse  1159 CLFPKLPRASLWSSCVVLPLLALTWMSAVLAMT--DRRSVLFQALFAVFNSAQGFVITAVHCFLR 1221

  Fly   655 RIYNEIMFKFGLQSNPSTASTRTRAGVTKSYAPTSTAMTTLRHSPGSCE 703
            |...:::              :.:.||.::        .....||.||:
Mouse  1222 REVQDVV--------------KCQMGVCRA--------DESEDSPDSCK 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl15NP_723538.3 Mth_Ecto <247..355 CDD:299804
7tm_4 385..646 CDD:304433 64/315 (20%)
Adgrb2XP_011238809.1 TSP1 305..353 CDD:214559
TSP1 358..408 CDD:214559
TSP1 413..463 CDD:214559
TSP1 469..519 CDD:214559
HormR 522..586 CDD:214468
GAIN 605..>760 CDD:374574
GPS 864..917 CDD:197639
7tmB2_BAI2 923..1234 CDD:320654 67/350 (19%)
TM helix 1 926..950 CDD:320654 6/17 (35%)
TM helix 2 960..981 CDD:320654 6/22 (27%)
TM helix 3 991..1013 CDD:320654 5/24 (21%)
TM helix 4 1031..1047 CDD:320654 8/18 (44%)
TM helix 5 1067..1090 CDD:320654 6/26 (23%)
TM helix 6 1145..1191 CDD:320654 6/45 (13%)
TM helix 7 1196..1221 CDD:320654 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7764
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.860

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