Protein Alignment mthl15 and mthl11

DIOPT Version :10

• Sequence 1: NP_723538.3
• Gene: mthl15 / 318914
• FlyBaseID: FBgn0051720
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 128/513 - (24%)
• Similarity: 216/513 - (42%)
• Gaps: 112/513 - (21%)

  Fly   232 DADLDRGALPEQKFLVRACQEMKICQKIPCIRRCCAEGEMYAKGNFSTYCKIDGTDFKFEGFQNL 296
            |.|.||.::|:.   :|.|    :|:...|||.||...::.| ||.   |..|       .::||
  Fly    65 DYDGDRVSVPKH---IRGC----VCKLKTCIRFCCHHKKLMA-GNL---CSQD-------VYENL 111

  Fly   297 ---------NINANFSKP---SDFGIVHGLQCP---KFRLDPDNFPDDSHTINPSNGSLIIHNTF 346
                     .:|.:..|.   :|..:...|..|   .:.||.:....|..::. .||||..|...
  Fly   112 TYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLY-ENGSLFRHFDQ 175

  Fly   347 KTYTNTQYCVERVRPNQ----KLYT----FLCFDN----------KVVTGDRIRFKMYPIGLLIS 393
            :..:..::|::   ||.    |.|:    |.|...          :.|...|:.....|: ...|
  Fly   176 RYLSKQEFCLQ---PNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPV-KFSS 236

  Fly   394 CCFYALTLIVYISIAKLRNLPGK----ILICL-------VSSLFAAYLGIALGQLRPTSNDDICF 447
            ..|..:|:..|:.:.|.|:|.||    ..|||       |.|||..:      :|:    ..||:
  Fly   237 VFFMVITIAAYLWLPKFRSLHGKCCNLYFICLAITFLLNVISLFGIF------ELK----TPICY 291

  Fly   448 LSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGW---GLPTLLTGI 509
            |:|:..||.:||.|.|:::.|||:|:.|...|.:...|:. |..|..|:...|   ||.|.:..:
  Fly   292 LTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNK-RSSFFNYNIIVWSSAGLLTCIIFL 355

  Fly   510 TIAFTKSDILPDAVRPNFGHGRCW-FTYDSFGSASLLFFSGPVGILFIINLVLFVLTMKYC---N 570
            ...|.::: |.:...|..|...|| ||.   |.::..:|..|:.||.|:|...|.||.:|.   |
  Fly   356 VDQFVETN-LDNPYNPAVGVFSCWIFTN---GWSATFYFYAPLAILIILNCASFFLTTRYIYVEN 416

  Fly   571 KVKNEIYKMQSLNSDKPVLKRRFFQDKTRFVMNTKLCFVMGITWLLEIVSILFYDHKKTFFW--- 632
            |...::     ||:.:|   ::..::...:.:..:|..:||.:|.|||::.:.   :....|
  Fly   417 KQNQKV-----LNNSEP---QKLSRNHANYRIYFRLFIIMGGSWFLEIIAFIC---EMENMWKPL 470

  Fly   633 -TISDSFNVLLGIFVFI-------IF-VFKRRIYNEIMFKFGLQSNPSTASTRTRAGV 681
             .::|..|...||.:|:       :| :.::||.|..:....|.:......:...|.|
  Fly   471 IILNDYINCSQGIIIFVATFCNHEMFRLIRKRIQNRNITSLELTNTSRPVESEKMADV 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:448329	28/122 (23%)
		7tmB3_Methuselah-like	379..665	CDD:410632	84/315 (27%)
		TM helix 1	381..406	CDD:410632	5/24 (21%)
		TM helix 2	415..437	CDD:410632	9/32 (28%)
		TM helix 3	447..474	CDD:410632	12/26 (46%)
		TM helix 4	492..512	CDD:410632	6/22 (27%)
		TM helix 5	537..569	CDD:410632	10/31 (32%)
		TM helix 6	595..622	CDD:410632	7/26 (27%)
		TM helix 7	627..654	CDD:410632	7/38 (18%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	39/160 (24%)
		7tmB3_Methuselah-like	236..504	CDD:410632	80/293 (27%)
		TM helix 2	258..280	CDD:410632	7/21 (33%)
		TM helix 3	291..318	CDD:410632	12/26 (46%)
		TM helix 4	335..355	CDD:410632	6/19 (32%)
		TM helix 5	383..412	CDD:410632	10/28 (36%)
		TM helix 6	433..460	CDD:410632	7/26 (27%)
		TM helix 7	468..493	CDD:410632	5/24 (21%)