Protein Alignment mthl15 and adgre13

DIOPT Version :10

• Sequence 1: NP_723538.3
• Gene: mthl15 / 318914
• FlyBaseID: FBgn0051720
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_073801130.1
• Gene: adgre13 / 100538238
• ZFINID: ZDB-GENE-150505-3
• Length: 738
• Species: Danio rerio
• Alignment Length: 801
• Identity: 149/801 - (18%)
• Similarity: 286/801 - (35%)
• Gaps: 246/801 - (30%)

  Fly     1 MNIGLSLVCL-------ILSGIS----KVLAVQLC------CAANSLLFKYRRTVDNAEIYQCA- 47
            :::||..|.:       .|:|.:    |.:.:..|      |..|:..|      :.|..|.|.
Zfish     7 LSLGLLFVVIEEIIMQDCLAGYNKQKGKCVEIDECERELLVCGENANCF------NTAGSYYCQC 65

  Fly    48 ---------------SAASNISELPDLAQVIG--KLIPPMGLGLEKAINDSGHSQFALSKC---- 91
                           :.|..| :..|:.:.:|  .:..|..    :.||:.|  .|| .||
Zfish    66 HGGFRAEGNKPPFNFTQADGI-QCKDIDECVGGSNICGPNA----ECINNEG--DFA-CKCRSGF 122

  Fly    92 ------------QNFSSLSISDLGERTLNLRNNS-CI------------GLL----NRRLIV--- 124
                        |....:.|:|..:..::..::: |:            |.:    ||..:.
Zfish   123 TANNGMLIFVVRQGVQCVDINDCVDGNIDCGSDAICVNTEGGYYCTCESGFISSSGNRTFLAGLD 187

  Fly   125 LSCEFEKNVPSQS--VGFVNKCCPQGFIYVSENNTCKPGESDFFVYTSIISSPIIFFDNTLNCSD 187
            :.| .:..:.||.  ....:|.|.:..:..:||  .|..|......||:::   :..|..:|.|:
Zfish   188 IQC-VDSKIASQEGCTNHTSKVCLESLLEQTEN--IKDKELPLDTVTSLLN---MVLDAAVNISE 246

  Fly   188 HRA------LVEYTLSSGKVHFHNNSLI--WKDGTNSLPSSKFCIEAIHDSDDADLDRGALPEQK 244
            ..:      |..|   ..:|..:|..|:  ....||:..:..|.:      ||.:       .:.
Zfish   247 SSSSAKPNELASY---GNRVLKNNEELVSTLVKPTNTSANVSFTL------DDVE-------GRV 295

  Fly   245 FLVRACQEMKICQKIPCIR--RCCAEGEM--YAKGN----------FSTYCKIDGTDFKFEGFQN 295
            |:|.....:   .:||.:.  .|..:.::  .||.|          ::|...:...||.:.....
Zfish   296 FMVGPHVTL---GQIPRLHTTNCSIDIDLIGIAKNNNETTAVVFLGYNTMENLLKADFFYSTNDT 357

  Fly   296 LN--------------INANFSKPSDFGIVH--------GLQCPKFRLDPDNFPDDSHTINPSNG 338
            :|              .|...|||.:|...|        .:.|..:::. :...|....:|.:..
Zfish   358 VNTMMSSVISVTLPKTTNTALSKPVNFTFRHIRGFDSSGSMHCVYWKIS-EWIVDGCSVLNTNRS 421

  Fly   339 SLI---IH-NTFKTYTNTQYCVERVRPNQKLYTFLCFDNKVVTGDRIRFKMYPIGLLISCCFYAL 399
            ..:   :| :||.....|.     ..|::              .|.:...:..:.:::...|::|
Zfish   422 FTVCSCVHLSTFALIMQTS-----SHPSE--------------NDSLLNVLNVVCVIVGLLFFSL 467

  Fly   400 TLIVYISIAKLRNLPG-----KILICLVSSLFAAYLGIALGQ-----LRPTSNDDICFLSGFFVY 454
            .|:.:   |..:..||     :|.||:  ||..|:|...|.|     :|  ....:|.:....::
Zfish   468 ALLTF---AFCQWGPGVNNVARINICI--SLLLAHLLFLLTQQFLSLIR--RQQMLCEVISGLLH 525

  Fly   455 FCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWYSCYGWGLPTLLTGITIAFTKSDIL 519
            |..::.|.||.|.:..::....:....|.:|.::.|. |:....|:.:..::.||:.|
Zfish   526 FLFLSGFVWMFIEAVLLFICVKNLSQISSQKRNVLRN-IFLCVIGYAVALVVVGISAA------- 582

  Fly   520 PDAVRPNFGHGRCWFTYDSFGSASLLFFSGPVGILFIINLVLFV---LTMKYCNKVKNEIYKMQS 581
              .|...:|..:||...|   ...:..|.|||.::..:|::||:   :::|...|..|.  .:..
Zfish   583 --VVPKGYGSEKCWIKMD---KGFIWSFLGPVTVILALNVILFIGIGVSLKSAFKKLNS--DVSQ 640

  Fly   582 LNSDKPVLKRRFFQDKTRFVMNTKLCFVMGITWLL-------EIVSILFYDHKKTFFWTISDSFN 639
            ||..|.::    |:...:||       |:|.:|:|       :::.|||.            ..|
Zfish   641 LNQTKIIM----FKTLAQFV-------VLGCSWILGFFTNSSKVLEILFL------------ILN 682

  Fly   640 VLLGIFVFIIF-VFKRRIYNE 659
            ...|.|:|:|: |..:.|..|
Zfish   683 SQQGTFIFLIYCVLNKGIRQE 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:448329	24/147 (16%)
		7tmB3_Methuselah-like	379..665	CDD:410632	67/302 (22%)
		TM helix 1	381..406	CDD:410632	3/24 (13%)
		TM helix 2	415..437	CDD:410632	10/31 (32%)
		TM helix 3	447..474	CDD:410632	5/26 (19%)
		TM helix 4	492..512	CDD:410632	4/19 (21%)
		TM helix 5	537..569	CDD:410632	9/34 (26%)
		TM helix 6	595..622	CDD:410632	6/33 (18%)
		TM helix 7	627..654	CDD:410632	6/27 (22%)
adgre13	XP_073801130.1	None