DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir31a and Ir75b

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	158/625 - (25%)
Similarity:	265/625 - (42%)	Gaps:	76/625 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LVKTKQAIVFSCLFKDFKEISLALMRINQFVSVVNLNQSYSLTSILTRENYARTSVMVNARCSGS 99
            :.|....::..|   ....::|.....|.|.....|:....|.......|..:..|.::..|..|
  Fly    15 MAKLSHVLILHC---SLSHLALLAQSKNIFTQFQPLHSDIQLNDDFLNHNILKLGVFLDINCDKS 76

  Fly   100 SELLFEASENRYFNKTYQWFLWGVDLE---VQSLFPLNLNYVGPNAQITYVNET--ADGYAYWDI 159
            ..:|..||..|:|:..|.|.::...:.   ::|.|.....:|  :|.:|||...  :..:..:|:
  Fly    77 GTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESHFKEAQIFV--DADVTYVTHDPFSKNFLLYDV 139

  Fly   160 HSKGRHLKSNLEINLIATLINDTLN--IAR---DIFHLQSIDFRGQFNGLTLRGASVIDKEDI-I 218
            ::|||.|...|.|.....:..:..|  :.|   :::...::..|..|.|||:|..:|:....: :
  Fly   140 YNKGRQLGGELNITADREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNV 204

  Fly   219 SNEQIESILSRPTKDAGVAAFIKYHYELLGLLRERFN--FTVNFRNSRGWAGRLGNTTFRLGLLG 281
            |.::|...::...: ..:..:.:..|:....||:..:  |...||:.  |:.  ||.|.  |::|
  Fly   205 SIKEIFDFMNSKYR-IQLDTYARLGYQARQPLRDMLDCKFKYIFRDR--WSD--GNATG--GMIG 262

  Fly   282 IVMRNEADIAASGAFNRINRFAEFDTIHQSWKFETAFLYRYTSDLDTHGKSGNFLSPFSDRVWL- 345
            .::.::||:|.:......:|......|.:...|....::|....:.....:..||.|||..|||
  Fly   263 DLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLT 327

  Fly   346 FCLLTLGAFSIIWVLFEIIDYKILRIRVNSQKLEHLNQ-KSSVICIKTTCIERILQTFGACCQQG 409
            |.||.|.|..::||.|               .||...| |.|::   |:|    |.:|||.|.||
  Fly   328 FALLLLLAGCLLWVTF---------------ILERRKQWKPSLL---TSC----LLSFGAGCIQG 370

  Fly   410 LDPNPVDRSVRFLVMTLFLFSLVMYNYYTSSVVGGLLSSS-DQGPSTVDEITASPLKISFEDIGY 473
            ....|.....|.....|.:.|.:|||||||.||..||... .....|:.::..|.|.:..|...|
  Fly   371 AWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVY 435

  Fly   474 YKVLFRESQNRSITRLIEKK-LSSSRSLNELPIFSHIEDAVPYLKAG--------GFAFHCEVVD 529
            .::....|:...:..|..|| |.|.||.:::.|.:         :||        ||.:...|..
  Fly   436 TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPT---------EAGVLSVRDQEGFVYITGVAT 491

  Fly   530 AYPVISEYFDANEICDLREVSGLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQI 594
            .|..:.::|.|::||:|.|:. |.:....:.:|.|.|.|.|:.|.:.....|.|...:..|....
  Fly   492 GYEFVRKHFLAHQICELNEIP-LRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWME 555

  Fly   595 KKPAC-QSLYTVYPVSLSGVLPGFVILICGFGASLLLLCL 633
            .|..| |..:|| .|.|....|.|:||:   ||  ::||:
  Fly   556 TKLHCYQHNHTV-AVGLEYAAPLFIILL---GA--IILCM 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	68/233 (29%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	93/335 (28%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	79/279 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010