DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir31a and grik1b

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	801	Identity:	148/801 - (18%)
Similarity:	265/801 - (33%)	Gaps:	218/801 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAAGEGEII-PSMEESV--VTNFVKSL-------------VKTKQAIVFSCLFKDFKEISLALMR 60
            ||.|...:. ||...||  |.:...:|             |..|.:...: |:.|:..||.|::.
Zfish   127 LALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDSFYIN-LYPDYASISRAVLD 190

  Fly    61 INQFVSVVNLNQSYSLTSILTR-----ENYARTSVMVNAR--CSGSSE---LLFEASENRYF--- 112
            |.||.....:...|...:.|.|     :..:|.|:.:..|  .:||.:   ||.|..:.:.|
Zfish   191 IVQFYKWKAVTVVYEDATGLIRLQELIKAPSRYSIKIKIRQLPTGSKDARPLLKEMKKGKEFCVI 255

  Fly   113 ---------------------NKTYQWFLWGVDLEVQSLFPLN-----------LNYVGPN---- 141
                                 .:.|.:|...:||....|.|..           ||...|.
Zfish   256 FDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSLDLEPFRYSGVNMTGFRLLNIDNPQVASV 320

  Fly   142 ---------------------------------------------AQITYVNETADGYAYWDIHS 161
                                                         :|||..:.....:..|...|
Zfish   321 VEKWSMERLQAPPKPETGLQDGMMTTEAALMYDAVYMVAAASQRASQITVSSLQCHRHKPWRFGS 385

  Fly   162 KGRHLKSNLEINLIA--TLINDTLNIARDIFHLQSIDFR----------GQFN------------ 202
            :...:....:.|.:.  .:||.|..:.:| |.|..|..:          |:||
Zfish   386 RFISMFKEAQWNGLTGQIIINKTDGLRKD-FDLDIISLKEDGLEKPLESGRFNKVWKKIGVWNSN 449

  Fly   203 -GLTLRGASVIDKE----DIISNEQ--IESILSRP-----TKDAGVAAFIKYHYELLGLLRE--- 252
             ||.|..::. ||.    |.::|..  :.:||..|     ..|..:....::....|.||:|
Zfish   450 TGLNLTDSNK-DKNTNVTDSMANRTLIVTTILENPYVMYKKSDKPLYGNDRFEGYCLDLLKELSN 513

  Fly   253 --RFNFTVNF--------RNSRG-WAGRLGNTTFRLGLLGIVMRNEADIAASGAFNRINRFAEFD 306
              .|::.|..        :|.:| |.          |::..::.:.||:|.:.......|....|
Zfish   514 ILGFSYEVKLVTDGKYGAQNDKGEWN----------GMVRELIDHVADLAVAPLTITYVREKVID 568

  Fly   307 TIHQSWKFETAFLYRYTSDLDTHGKSG------NFLSPFSDRVWLFCLLT-LGAFSIIWVLFEII 364
            ..........:.||        |..:|      :||:|.|..:|::.||. ||...:::|:....
Zfish   569 FSKPFMTLGISILY--------HKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 625

  Fly   365 DYKILRIRVNSQKLEH-LNQKSSVICIKTTCIERILQTFGACCQQGLDPNPVDRSVRFLVMTLFL 428
            .|:...        .| .|..|.|:....|.|..:....||..|||.:..|...|.|.:....:.
Zfish   626 PYEWYN--------PHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWF 682

  Fly   429 FSLVMYNYYTSSVVGGLLSSSDQGPSTVDEITASPLKISFEDI--GYYKVLFRESQNRSITRLIE 491
            |:|::.:.||:::...|.......|....:..|...||.:..:  |.....|::|:    ....|
Zfish   683 FTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSK----ISTYE 743

  Fly   492 KKLSSSRSLNELPIFSHIEDAVPYLKAGGFAFHCEVVDAYPVISEYFDANEICDLREVSGLMEVE 556
            |..:...|.....:..:..:.:..:....:|...|....     ||..... |:|.::.||::.:
Zfish   744 KMWAFMSSRKNTALVKNNREGIQRVLTTDYALLMESTSI-----EYISQRN-CNLTQIGGLIDSK 802

  Fly   557 ILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQIKKPAC-----QSLYTVYPVSLSGVLPG 616
            .........|.|.:....|:...||:|.: .:::.:..:...|     :....:...::.|:
Zfish   803 GYGVGTPIGSPYRDKVTIAILQLQEEGKL-HMMKEKWWRGNGCPEEDSKEASALGVENIGGI--- 863

  Fly   617 FVILICGFGASLLLLCLEKVY 637
            |::|..|...|:.:...|.:|
Zfish   864 FIVLAAGLVLSVFVAIGEFIY 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	41/229 (18%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	58/329 (18%)
		ANF_receptor	80..423	CDD:279440	53/297 (18%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	78/405 (19%)
		Lig_chan	602..871	CDD:278489	54/290 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910