DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir31a and grik4

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	680	Identity:	146/680 - (21%)
Similarity:	256/680 - (37%)	Gaps:	155/680 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IIPSMEESVVTNFVKSLVKTKQAIV-FSC------LFKDFKEISLALMRINQFVSVVNLNQSYSL 76
            |:.|:|.|::.  :..|...:..|| ||.      .|:||               |::||:|:
Zfish   244 ILTSLEFSLLR--LDDLADQRVNIVGFSVFNRTHPFFQDF---------------VLSLNRSW-- 289

  Fly    77 TSILTREN-----YARTSVMVNARCSGSSELLFEASE---------NRYFN--------KTYQWF 119
                 :||     :|.|.:        ||.|||:|..         ||..|        |:.:.:
Zfish   290 -----QENCDHAPFAGTPL--------SSALLFDAVHTVVAAVQELNRSQNVGATQLSCKSSKIW 341

  Fly   120 LWGVDL-------EVQSLF-PLNLNYVG--PNAQITYVNETADG---YAYWDIHS-KGRHLKSNL 170
            ..|..|       |::.|. .:..|..|  .|..:..:..:.||   ...|  || :|..::..|
Zfish   342 EHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALRIMQNSRDGLRQIGQW--HSEQGLSMERKL 404

  Fly   171 -EINLIATLINDTLNIARDIFHLQSIDFRGQFNGLTLRGASVIDKEDIISNEQIESILSRPTKDA 234
             .:|:..||.|.||.|. .|.....:..|.             :.:::..|::.|.......|:.
Zfish   405 PSLNVTDTLFNTTLTIT-TILENPYVMLRA-------------NHQELEGNDRYEGFCVDMLKEL 455

  Fly   235 GVAAFIKYHYELLGLLRERFNFTVNFRNSRGWAGRLGNTTFRLGLLGIVMRNEADIAASGAFNRI 299
            ......||...|:|            ....|..|..|..|   |::|.::..:||:|.:......
Zfish   456 ADILKFKYRIRLVG------------DGVYGVPGANGTWT---GMVGELISRKADLAVAALTITA 505

  Fly   300 NRFAEFDTIHQSWKFETAFLYRYTSDLDTHGKSG--NFLSPFSDRVWLFCLLTLGAFS-IIWVLF 361
            .|....|..........:.:||    :....:.|  :||.|||..||||.||...|.| :::::.
Zfish   506 EREKVIDFSKPFMTLGISIMYR----VHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   362 EIIDYKILRIRVNSQKLEHLNQKSSVICIKTTCIERILQ---------TFGACCQQGLDPNPVDR 417
            .:..|            |..|...   |:|..|...|.|         ..|...|||....|...
Zfish   567 RLTPY------------EWYNPHP---CLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRAL 616

  Fly   418 SVRFLVMTLFLFSLVMYNYYTSSVVGGLLSSSDQGP-STVDEITASPLKISFEDI--GYYKVLFR 479
            |.|.:....:.|:|::.:.||:::...|.....:.| .:||:: |....|.:..:  |.....|:
Zfish   617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDL-ADQTAIEYGTMHGGSTMTFFQ 680

  Fly   480 ESQNRSITRLIEKKLSSSRSLNELPIFSHIEDAVPYLKAGGFAFHCEVVDAYPVISEYFDANEIC 544
            .|:.::..|:.....|...|:    .....|:.:..:....:|:..|     ..::||:.... |
Zfish   681 NSRYQTYQRMWNFMYSKQPSV----FVKSTEEGIARVLNSNYAYLLE-----STMNEYYRQRN-C 735

  Fly   545 DLREVSGLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQIKKPAC--QSLYTVYP 607
            :|.::.||::.:.....:...|.|.:.|..|:...||:..:| ||:|:......|  :..:....
Zfish   736 NLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLE-ILKRKWWDGGKCPKEEDHRAKG 799

  Fly   608 VSLSGVLPGFVILICGFGASLLLLCLEKVY 637
            :.:..:...||:|:||...::.:..||.|:
Zfish   800 LGMENIGGIFVVLVCGLLVAIFMAVLEFVW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	47/227 (21%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	43/189 (23%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	85/418 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910