DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir31a and GRIN2B

DIOPT Version :9

Sequence 1:NP_001260346.1 Gene:Ir31a / 318912 FlyBaseID:FBgn0051718 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:550 Identity:96/550 - (17%)
Similarity:172/550 - (31%) Gaps:203/550 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 SGSSELLFEAS---------ENRYFNKTYQWFLWGVDLEVQSLFPLNLNYVGPNAQITYVNETAD 152
            :.:|::|.|.|         .|.:..:.||       ..:.:.:.:|:.:.|.|     ::.:.|
Human   302 TAASDMLSEHSFIPEPKSSCYNTHEKRIYQ-------SNMLNRYLINVTFEGRN-----LSFSED 354

  Fly   153 GYAYWDIHSKGRHLKSNLEINLIATLIN-----------------------------------DT 182
            ||   .:|.|           |:..|:|                                   |.
Human   355 GY---QMHPK-----------LVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDH 405

  Fly   183 LNIA----RDIFHLQSIDFRGQFNGLTLRGASVIDKEDIISNEQIE--------------SILSR 229
            |:|.    .....::|:|   ..:|..:|......|..:..|:..|              .||.:
Human   406 LSIVTLEEAPFVIVESVD---PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKK 467

  Fly   230 PTKDAGVAAFIKYHYELLGLLRERFNFTVNFRNSRGWAGRLGNTTFRLGLLGIVMRNEADIAASG 294
            .:|.      :|:.|:|             :..:.|..|:..|.|:. |::|.|:...|.:|...
Human   468 ISKS------VKFTYDL-------------YLVTNGKHGKKINGTWN-GMIGEVVMKRAYMAVGS 512

  Fly   295 AFNRINRFAEFDTIHQSWKF-ETAFLYRYTSDLDTHGKSGNFLSPFSDRVWLF---CLLTLGAFS 355
            .  .||. ...:.:..|..| ||......:....|...|. ||.|||..||:.   .||.:.|.:
Human   513 L--TINE-ERSEVVDFSVPFIETGISVMVSRSNGTVSPSA-FLEPFSADVWVMMFVMLLIVSAVA 573

  Fly   356 I-IWVLFEIIDYKILRIRVNSQKLEHLNQKSSVICIKTTCIERILQTFGACCQQGLDP------- 412
            : ::..|..:.|                                    ..|...|.:|       
Human   574 VFVFEYFSPVGY------------------------------------NRCLADGREPGGPSFTI 602

  Fly   413 -------------------NPVDRSVRFLVMTLFLFSLVMYNYYTSSVVGGLLSSSDQGPSTVDE 458
                               ||...:.:.:|.....|:::....||:::...::..     ..||:
Human   603 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE-----EYVDQ 662

  Fly   459 ITASPLKISFEDIGYYKVLFR--ESQNRSITRLIEKKLSSSRS----LNELPIFSHIEDAVPYLK 517
            ::....| .|:....:...||  ...|.|..|.|....:...:    .|:    ..::||:..||
Human   663 VSGLSDK-KFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQ----RGVDDALLSLK 722

  Fly   518 AGGF-AFHCEVVDAYPVISEYFDANEICDL 546
            .|.. ||   :.|| .|::.....:|.|.|
Human   723 TGKLDAF---IYDA-AVLNYMAGRDEGCKL 748

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir31aNP_001260346.1 Lig_chan 401..624 CDD:278489 32/178 (18%)
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 18/116 (16%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 77/422 (18%)
HisJ <459..>542 CDD:223904 21/105 (20%)
Lig_chan 557..829 CDD:278489 39/241 (16%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 0/18 (0%)