DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir31a and GRIK4

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	693	Identity:	150/693 - (21%)
Similarity:	263/693 - (37%)	Gaps:	146/693 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLLISMFILILAAGEGEIIPSMEESVVTNF------VKSLVKTKQAIV-FS------CLFKDFKE 53
            |..:|..||:.||..| ::.:....:.||.      :.|||..:..|: ||      ..|::|.:
Human   220 NASMSHTILLKAAELG-MVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQ 283

  Fly    54 ISLALMRINQFVSVVNLNQSYSLTSILTRENYARTSVMVNARCSGSSELLFEA-----SENRYFN 113
                           :||||:       :||.........|.   ||.|||:|     :..:..|
Human   284 ---------------SLNQSW-------QENCDHVPFTGPAL---SSALLFDAVYAVVTAVQELN 323

  Fly   114 KTYQ-------------W--------FLWGVDLE-VQSLFPLNLNYVGPNAQITYVNETADGY-- 154
            ::.:             |        :|..|:|| :......|......|..:..:..|.:|:
Human   324 RSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQ 388

  Fly   155 -AYWDIHSKGRHLKSNL-EINLIATLINDTLNIARDIFHLQSIDFRGQFNGLTLRGASVIDKEDI 217
             ..|.: ::|..:.|:| ..|:..||.|.||.:...:          :...|.|:|    :.:::
Human   389 IGQWHV-AEGLSMDSHLYASNISDTLFNTTLVVTTIL----------ENPYLMLKG----NHQEM 438

  Fly   218 ISNEQIESILSRPTKDAGVAAFIKYHYELLGLLRERFNFTVNFRNSRGWAGRLGNTTFRLGLLGI 282
            ..|::.|.......|            ||..:|  |||:.:.......:.....|.|: .|::|.
Human   439 EGNDRYEGFCVDMLK------------ELAEIL--RFNYKIRLVGDGVYGVPEANGTW-TGMVGE 488

  Fly   283 VMRNEADIAASGAFNRINRFAEFDTIHQSWKFETAFLYRYTSDLDTHGKSG--NFLSPFSDRVWL 345
            ::..:||:|.:|......|....|..........:.|||    :....|.|  :||.|||..|||
Human   489 LIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR----VHMGRKPGYFSFLDPFSPGVWL 549

  Fly   346 FCLLTLGAFSIIWVLFEIIDYKILRIRVNSQKLEHLNQKSSVICIKTTCIERILQ---------T 401
            |.||...|.|.  |||.:            .:|......|...|.:..|...:.|         .
Human   550 FMLLAYLAVSC--VLFLV------------ARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP 600

  Fly   402 FGACCQQGLDPNPVDRSVRFLVMTLFLFSLVMYNYYTSSVVGGL-LSSSDQGPSTVDEITASPLK 465
            .|...|||....|...|.|.:....:.|:|::.:.||:::...| :...|....:||:: |....
Human   601 VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDL-ADQTA 664

  Fly   466 ISFEDI--GYYKVLFRESQNRSITRLIEKKLSSSRSLNELPIFSHIEDAVPYLKAGGFAFHCEVV 528
            |.:..|  |.....|:.|:.::..|:.....|...|:    .....|:.:..:....:||..|
Human   665 IEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSV----FVKSTEEGIARVLNSNYAFLLE-- 723

  Fly   529 DAYPVISEYFDANEICDLREVSGLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQ 593
               ..::||:.... |:|.::.||::.:.....:...|.:.:.|..|:...||...:| ||:|:.
Human   724 ---STMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLE-ILKRKW 783

  Fly   594 IKKPAC--QSLYTVYPVSLSGVLPGFVILICGFGASLLLLCLE 634
            .:...|  :..:....:.:..:...||:||||...::.:..||
Human   784 WEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	49/227 (22%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	42/206 (20%)
		ANF_receptor	43..382	CDD:279440	38/187 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	94/428 (22%)
		Lig_chan	547..816	CDD:278489	65/294 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12593
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860