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Protein Alignment Ir31a and GRIA3

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	677	Identity:	139/677 - (20%)
Similarity:	233/677 - (34%)	Gaps:	159/677 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IPSMEESVVTNFVKSLVKTKQAIVFSCLFKDFKEISLALMRINQFVSVVNLNQSYSLTSILTRE- 83
            |.:.|..:|..|::..|:..:        ::|.|..               |.....||.||.:
Human   272 IVNNENPMVQQFIQRWVRLDE--------REFPEAK---------------NAPLKYTSALTHDA 313

  Fly    84 --------NYARTS-VMVNARCSGSSELLFEASENRYFNKTYQWFLWGVDLEVQSLFPLNLNYVG 139
                    .|.|.. |.|:.|.|....|.         |....| ..|:|:| ::|..:.:..:.
Human   314 ILVIAEAFRYLRRQRVDVSRRGSAGDCLA---------NPAVPW-SQGIDIE-RALKMVQVQGMT 367

  Fly   140 PNAQI-TY---VNETADGY----------AYWDIHSKGRHLKSNLEINLIATLINDTLNIARDIF 190
            .|.|. ||   .|.|.|.|          .||:.:.:..........|..|:..|.|: :...|.
Human   368 GNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTI-VVTTIL 431

  Fly   191 HLQSIDFRGQFNGLTLRGASVIDKEDIISNEQIESILSRPTKDAGVAAFIKYHYELLGLLRERFN 255
            ....:.::.             :.|.:..||:.|........:......|||...::|
Human   432 ESPYVMYKK-------------NHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVG------- 476

  Fly   256 FTVNFRNSRGWAGRLG----NTTFRLGLLGIVMRNEADIAASGAFNRINRFAEFDTIHQSWKFET 316
                       .|:.|    .|....|::|.::...||||.:.....:.|....|       |..
Human   477 -----------DGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVID-------FSK 523

  Fly   317 AFLYRYTSDL---DTHGKSG--NFLSPFSDRVWLFCLLTLGAFSIIWVLFEIIDYKILRIRVNSQ 376
            .|:....|.:   ....|.|  :||.|.:..:|: |::    |:.|.|  .::.:.:.|......
Human   524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM-CIV----FAYIGV--SVVLFLVSRFSPYEW 581

  Fly   377 KLEHLNQKSSVICIKTTCIERILQ-----------------TFGACCQQGLDPNPVDRSVRFLVM 424
            .||..|::           .|..|                 :.||..|||.|.:|...|.|.:..
Human   582 HLEDNNEE-----------PRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 635

  Fly   425 TLFLFSLVMYNYYTSSVVGGLLSSSDQGPSTVDEITASPLKISFE--DIGYYKVLFRESQNRSIT 487
            ..:.|:|::.:.||:::...|.......|....|..|...:|::.  |.|..|..||    ||..
Human   636 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFR----RSKI 696

  Fly   488 RLIEKKLSSSRSLNELPIFSHIEDAVPYLK--AGGFAFHCEVVDAYPVISEYFDANEICDLREVS 550
            .:.||..|..:|...........|.|..::  .|.|||..|     ..::||.:..:.||..:|.
Human   697 AVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLE-----STMNEYIEQRKPCDTMKVG 756

  Fly   551 GLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQIKKPAC-----QSLYTVYPVSL 610
            |.::.:.......|.|........|:....|:|.::::..:....|..|     .|......:||
Human   757 GNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSL 821

  Fly   611 SGVLPGFVILICGFGASLLLLCLEKVY 637
            |.|...|.||:.|.|.::::..:|..|
Human   822 SNVAGVFYILVGGLGLAMMVALIEFCY 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.