DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir31a and nmr-2

DIOPT Version :9

Sequence 1:	NP_001260346.1	Gene:	Ir31a / 318912	FlyBaseID:	FBgn0051718	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001256640.1	Gene:	nmr-2 / 180002	WormBaseID:	WBGene00003775	Length:	990	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	140/664 - (21%)
Similarity:	208/664 - (31%)	Gaps:	229/664 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LFPLNLNYVGPNAQITYVN----ETADGYAYWD------IHSKGRHLKSN--------------- 169
            ||...|..:.||...:..:    ::.||..|||      .|.|...:|.|
Worm   338 LFGAALLQLRPNEMFSLKSNVSCKSEDGDPYWDNGKYIYEHMKAAFVKGNPFHVDDGHDSFFYTF 402

  Fly   170 ----------LEINLIAT-------------LINDTLNI---------------ARDIFHLQSID 196
                      |:|:.:.|             ..|:.|.:               |.|.||::.:
Worm   403 EKTGRLRNSILQISNLRTNSKGEKTWEKVGIFTNNELKMADVQWPGEKANPPQGAADKFHVKVV- 466

  Fly   197 FRGQFNGLTLRGASVIDKEDIISNEQ--------------IESILSRPTKDAGV---AAFIK--- 241
                    ||.....|...|:..:.|              :|.     |..|||   ...:|
Worm   467 --------TLHEPPFIAVSDVDPDTQKCPGNQGSICDWGDVEY-----TDGAGVKKNRTLLKCCS 518

  Fly   242 -YHYELLGLLRERFNFTV----------NFRNSRGWAGRLGNTTFRLGLLGIVMRNEADIAASGA 295
             |..:||..|.....||.          ..:...||.          ||:..:|.|:||:..:..
Worm   519 GYCVDLLNKLANDIGFTYTLYKVRDEKWGLKTENGWN----------GLIADLMHNKADMCVTSL 573

  Fly   296 FNRINRFAEFDTIHQSWKFETAFLYRYTSDLDTHG-------KSG-----NFLSPFSDRVW---L 345
            .....|..:.|       |...|       ||| |       :||     .||.||....|   |
Worm   574 KLNSERARDID-------FSLPF-------LDT-GISIIVKIRSGVLSPTAFLEPFEYSTWVIIL 623

  Fly   346 FCLLTLGAFSIIWVLFE-IIDYKILRIRVNSQKLEHLNQKSSVI----CIKTTCIERILQTFGAC 405
            |..:.:.|.||.  ||| :..|..     |.||......|.|:.    .:..|       .|.|.
Worm   624 FVCIHVAAISIF--LFEWVSPYSF-----NMQKYPPPEHKFSLFRSYWLVWAT-------LFSAS 674

  Fly   406 CQQGLDPNPVDR---------SVRFLV-----MTLFLFSLVMYNYYTSSVVGGLLS-SSDQGPST 455
            ....:..:.|.|         .:.||.     :..|:.:.|.| |..|.:...:|: ..||.|
Worm   675 VSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAAFMITRVQY-YDLSGIHDPMLNFPHDQKP-- 736

  Fly   456 VDEITASPLKISFEDIGYYKVLFRESQNRSITRLIE-KKLSSSRSLNELPIFSHIEDAVPYLKAG 519
                   |.:....|.|.    ..|:..|:..::.| .|.:....:|              :.||
Worm   737 -------PFRFGTVDGGN----THETMKRNWHKMHEYVKHNKYFRMN--------------ISAG 776

  Fly   520 GFAFHCEVVDAY---PVISEYF---DANEICDLREVSGLMEVEILNWILHKNSQYTEIFKTAMCN 578
            ..|...|.:||:   .|:.:|:   |||  |.|..|.....:........|||.:|.:....|..
Worm   777 IEAVKNEELDAFIYDAVVLDYWAGKDAN--CALMTVGKWASMTGYGIGFPKNSPHTSLVNHYMLQ 839

  Fly   579 AQEKGFVERILR--RRQIKKPACQSLYTVYPVSLSGVLPGFVILICGFGASLLLLCLEKVYA--- 638
            .|:||.:||:..  ......|...|.....|:.:...|..||:|..|...|:::|..|.:|.
Worm   840 YQQKGDLERLQNFWLTGACTPDSHSQTQSAPLGIENFLSAFVLLAGGIIVSVIVLGFEHIYCMHL 904

  Fly   639 -----HFGPRKFCG 647
                 ...|..:||
Worm   905 RKPLQKIDPNGWCG 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir31a	NP_001260346.1	Lig_chan	401..624	CDD:278489	54/246 (22%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	19/104 (18%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	104/482 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910